Flashcards in Other sedative-hypnotic drugs Deck (17)
Other sedative-hypnotic drugs - 5 drugs
Zolpidem - MOA
Selective targeting of GABAA receptors that are composed of α1 subunits (omega1 site)
Zolpidem - indications
Zolpidem and zaleplon - adverse effects
Dizziness, drowsiness, headache
Zolpidem, zaleplon and eszopiclone - interactions
Alcohol & CNS depressants: potentiated effect
Zolpidem, zaleplon, eszopiclone, ramelteon - duration of action
Zolpidem - Short.
Zaleplon - Very short.
Eszopiclone - Short.
Ramelteon - Short.
Which of the other sedative-hypnotic drugs are category B for pregnancy?
Zolpidem and zaleplon
Zaleplon - indications
Insomnia, medsleep awakenings
Eszopiclone - adverse effects
Dizziness, drowsiness, difficulty with coordination
Eszopiclone - indications
Melatonin - MOA
Principal mediator of the biologic clock that determines circadian, seasonal and reproductive rhythms. Released before onset of sleep and cause drowsiness that facilitates sleep.
Melatonin - indications
Jet lags, insomnia in shift-change workers.
Insomnia in elderly pts with melatonin deficiency, delayed sleep-phase syndrome.
Non-24-hour sleep-wake disorder.
Ramelteon - MOA
Acts selectively on melatonin receptors
Ramelteon - indications
Ramelteon - contraindications
Coadm with fluvoxamine (SSRI, strong CYP1A2 inhibitor): increases ramelteon levels by 70-fold.
Ramelteon - adverse effects
Dizziness, drowsiness, alteration of reproductive hormones