Other sedative-hypnotic drugs Flashcards Preview

19 Sedative, hypnotic, anxiolytic drugs > Other sedative-hypnotic drugs > Flashcards

Flashcards in Other sedative-hypnotic drugs Deck (17)
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1

Other sedative-hypnotic drugs - 5 drugs

Zolpidem
Zaleplon
Eszopiclone
Melatonin
Ramelteon

2

Zolpidem - MOA

Selective targeting of GABAA receptors that are composed of α1 subunits (omega1 site)

3

Zolpidem - indications

Insomnia

4

Zolpidem and zaleplon - adverse effects

Dizziness, drowsiness, headache

5

Zolpidem, zaleplon and eszopiclone - interactions

Alcohol & CNS depressants: potentiated effect

6

Zolpidem, zaleplon, eszopiclone, ramelteon - duration of action

Zolpidem - Short.
Zaleplon - Very short.
Eszopiclone - Short.
Ramelteon - Short.

7

Which of the other sedative-hypnotic drugs are category B for pregnancy?

Zolpidem and zaleplon

8

Zaleplon - indications

Insomnia, medsleep awakenings

9

Eszopiclone - adverse effects

Dizziness, drowsiness, difficulty with coordination

10

Eszopiclone - indications

Insomnia

11

Melatonin - MOA

Principal mediator of the biologic clock that determines circadian, seasonal and reproductive rhythms. Released before onset of sleep and cause drowsiness that facilitates sleep.

12

Melatonin - indications

Jet lags, insomnia in shift-change workers.
Insomnia in elderly pts with melatonin deficiency, delayed sleep-phase syndrome.
Non-24-hour sleep-wake disorder.

13

Ramelteon - MOA

Acts selectively on melatonin receptors

14

Ramelteon - indications

Sleep-onset insomnia

15

Ramelteon - contraindications

Coadm with fluvoxamine (SSRI, strong CYP1A2 inhibitor): increases ramelteon levels by 70-fold.

16

Ramelteon - adverse effects

Dizziness, drowsiness, alteration of reproductive hormones

17

Ramelteon - interactions

Alcohol, CNS depressants: potentiation of effects. Fluvoxamine: increased plasma ramelteon levels.