Barbiturates Flashcards Preview

19 Sedative, hypnotic, anxiolytic drugs > Barbiturates > Flashcards

Flashcards in Barbiturates Deck (13)
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1

Barbiturates - 4 drugs

Amobarbital
Pentobarbital
Thiopental
Phenobarbital

2

Barbiturates - MOA

Bind to allosteric site on GABAA receptor-chloride ion channel. Increase the affinity of the receptor for GABA and duration for the channel to be open.
Also act directly to increase chloride influx in the absence of GABA.

3

Barbiturates - effects

Respiratory depression, coma, death.
Anxiolytic effect associated with considerable sedation.
Do not cause significant muscle relaxation.
Suppress slow-wave and REM sleep.v

4

Barbiturates - contraindications

Porphyria

5

Barbiturates - adverse effects

CNS depression.
Respiratory depression, coma, death.
Daytime sedation and hangover.
Physical dependence, withdrawal syndrome

6

Barbiturates - interactions

Induce cytochrome P450, accelerate their own and other drugs metabolism.
Induce α-aminolevulinate - exacerbate porphyria.
Potentiate effects of other CNS depressants.

7

Short-acting barbiturate(s)

Pentobarbital, thiopental

8

Medium-acting barbiturate(s)

Amobarbital

9

Long-acting barbiturate(s)

Phenobarbital

10

Which barbiturates are indicated for insomnia?

Amorbital, pentobarbital

11

Phenobarbital - indications

Seizure disorders

12

Thiopental - indications

Induction for anesthesia

13

Barbiturates - administratino

Amobarbital, pentobarbital, phenobarbital: oral adm.
Thiopental: IV