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Flashcards in Biochem tests Deck (17):
1

Prostate specific antigen

diagnostic test for prostate cancer however you can get high PSA levels in those who have benign prostatic disease as well

flags up that there may be prostate cancer but needs to be confirmed by biopsy

2

sensitivity

ability of test to determine people who have the disease

3

specificity

ability of test to determine people without the disease

4

What is AFP

Tumour marker used in germ cell tumuours

5

Where is alkaline phosphate found

Liver
biliary tree
placenta
bone - can be raised in metastasis when tumours invade bone
Small intestine

6

What to do if raised alk phos

GGT to check if its liver or something else

7

What kind of issue effusion do people with cardiac failure have

transudates

8

What kind of effusion do people with cancer tend to have

exudate

9

what does hypercalcaemia affect

effects neuromuscular contractility

10

What does raised calcium suggest

malignancy

11

What does hypercalcaemia cause

stones - renal stones
bones -bpne pain
groans -abdo pain
moans - depression

12

Effect of high calcium on kidneys

Presents sodium reabsorption in the kidneys resulting to sodium and water loss in urine - causes dehydration

13

What do parathyroid glands control

serum calcium

14

What does parathyroid hormone do

regulates levels of serum calcium therefore a squamous cell lung cancer releasing hormones mimicking parathyroid hormone causes hypercalcaemia

15

Cushings syndrome

excess cortisol in blood
can be caused by giving too many steroids
Caused by ACTH being secreted by malignancy

16

Conn's syndrome

excess aldosterone

17

Symptoms of cushings

Hypertension
hypocalcaemia
nocturia
mild truncal obestisty
plethora (excess fluid)
oedema