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Flashcards in How cancers behave Deck (24):
1

What do epithelial cells do

Line the inside and outside of the body resting on a basement membrane

2

Outside exposure epithelium

squamous epithelium

3

skin

keratinising with adnexal structures

4

Internal

Non-keratonising

5

What types of glandular epithelium are there

G cells, parental cells, chief cells ect

6

what is ciliated epithelium

speudostratified ciliated columnar

7

transitional epithelium

bladder

8

What does carcinoma mean

EPITHELIAL malignancy

9

The older you are the higher the risk is for an epithelial malignancy true/false

true
due to long term accumulation of environmental risk factors

10

Who rarely gets carcinomas

Children

children tend to get blood, brain and bone cancer

11

what are brain lesions in older patients

carcinoma metastasis unless proven otherwise

12

What is the disease progression of carcinomas

Local growth
spread via haematogenous and lymphatic routes
different patterns of spread for different tumours

13

metastasis from lung goes to

bone
brain
adrenal
liver

Breast cancers also commonly go here

14

Where do GI malignancies metastasise to

Liver

15

Where does prostate cancer metastasise to

anywhere

16

Smooth muscle cancer

leiomyoma/sarcoma

17

skeletal muscle

Rhabdomyosarcoma / sarcoma

18

Sarcoma spread

Mainly local invasion - get v big

little lymphatic spread

19

what do sarcomas look like

spindle cell lesions - elongated and tapered shape to cells. Solid.

20

What suggests lymphoma

large lymph nodes across areas that dont fit with anatomical drainage of an epithelial malignancy

may involve liver and spleen - organomegaly

21

Melanoma

malignant tumour of melanocytes (melanin forming cell in skin)

22

Brain tumours

Gliomas
v rare
lesions in the brain - metastatic unless proven otherwise
dont really spread anywhere else due to blood brain barrier

23

types of lung cancer

small cell
large cell
squamous cell
adenocarcinoma

24

How do differentiate between lung cancers

test for the molecular abnormality so you can treat that