Genetics of cancer Flashcards Preview

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Flashcards in Genetics of cancer Deck (13):
1

which feature of cancer cells allows them to acquire new characteristics

genomic instability

2

How is cancer commonly inherited

multifactorial inheritance

3

Which type of mutation is most likely to directly activate an oncogene

A splice site mutation

4

A healthy 42 year old woman who's mother had bowel cancer at 75 but no other family history of cancer. What is the risk

Marginally above population risk

any family history of cancer marginally increases the risk

5

cancer is a disease of mosaicism true/fale

True

largely caused by post-zygotic mutations - mutations for cancer often already present when they are born

6

Key pathways for cancer mutations

DNA damage and repair genes

7

DNA strand breaks in what mutation

BRCA1 BRCA2

8

Stages of cancer cell developing

Proliferation
Invasion
Metastasis

9

Characteristics needed for cells to evolve to cancer

genetic instability

10

genes involved in cancer

oncogenes - switch on for cell division
tumour suppressors - switch on and they suppress cell devision
DNA repair genes - repair DNA damage
Drug metabolism

11

Driver mutations

responsible for cancer phenotype in cells - drive characteristics of cancers

12

cancers are homogenous true/false

false
different clones/cell lines within every cancer

13

Knudson's two hit hypothesis

Inherited mutation - first hit
acquired mutation - second hit

OR

acquired mutation - first hit
acquired mutation - second hit