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Flashcards in Biochemistry Deck (47):
1

What is the rate-limiting enzyme for Glycolysis?

Phosphofructokinase-1

2

What is the rate-limiting enzyme for Gluconeogenesis?

Fructose-1,6-Bisphosphatase

3

What is the rate-limiting enzyme for Glycogenesis?

Glycogen Synthase

4

What is the rate-limiting enzyme for Glycogenolysis?

Glycogen Phosphorylase

5

What is the rate-limiting enzyme for The TCA cycle?

Isocitrate Dehydrogenase

6

What is the rate-limiting enzyme for the Hexose Monophosphate Pathway?

Glucose-6-Phosphate Dehydrogenase

7

What is the rate-limiting enzyme for cholesterol synthesis?

HMG-CoA reductase

8

What is the rate-limiting enzyme for Beta-Oxidation?

Carnitine acyltransferase I

9

What is the rate-limiting enzyme for the Urea Cycle?

Carbamoyl phosphate synthetase I

10

What is the rate-limiting enzyme for De novo pyrimidine synthesis?

Carbamoyl phosphate synthetase II

11

What is the rate-limiting enzyme for Fatty acid synthesis?

Acetyl-CoA carboxylase

12

What is the rate-limiting enzyme for De novo purine synthesis?

Glutamine-Phosphoribosylphosphate aminotransferase

13

What is the rate-limiting enzyme for Ketogenesis?

HMG-CoA synthase

14

Hexokinase has ____ affinity and _____ capacity (Vmax) compared to glucokinase.

Increased; decreased

15

Glucokinase has ____ affinity and _____ capacity (Vmax) compared to hexokinase.

Decreased; increased

16

_____ has negative feedback on glucokinase.

Fructose-6-Phosphate

17

_____ has negative feedback on hexokinase

Glucose-6-Phosphate

18

Name the irreversible enzymes in gluconeogenesis and their locations.

Pyruvate carboxylase (mitochondria), Phosophoenolpyruvate kinase (cytosol), Phosphofructokinase-2 (cytosol), Glucose-6-Phosphatase (ER)

19

Which amino acid is the precursor for dopamine?

Phenylalanine

20

Which amino acid is the precursor for Niacin?

Tryptophan

21

Which amino acid is the precursor for Melatonin?

Tryptophan

22

Which amino acid is the precursor for Serotonin?

Tryptophan

23

Which amino acid is the precursor for heme?

Glycine

24

Which amino acid is the precursor for Glutathione?

Glutamate

25

Which amino acid is the precursor for Creatine?

Arginine

26

Which amino acid is the precursor for Nitric oxide?

Arginine

27

Which enzyme is deficient in von Gierke Disease?

Glucose-6-Phosphatase

28

Which enzyme is deficient in Pompe Disease?

Alpha-1,4-glucosidase

29

Which enzyme is deficient in Cori Disease?

Alpha-1,6-glucosidase (Debranching enzyme)

30

Which enzyme is deficient in McArdle Disease?

Glycogen phosphorylase

31

Which enzyme is deficient in Gaucher Disease?

Glucocerebrosidase

32

Which enzyme is deficient in Fabry Disease?

Alpha-galactosidase A

33

Which enzyme is deficient in Niemann-Pick Disease?

Sphingomyelinase

34

Which enzyme is deficient in Tay-Sachs Disease?

Hexosaminidase A

35

Which enzyme is deficient in Krabbe Disease?

Galactocerebrosidase

36

Which enzyme is deficient in Metachromic leukodystrophy?

Arylsulfatase A

37

Which enzyme is deficient in Hurler Syndrome?

alpha-L-iduronidase

38

Which enzyme is deficient in Hunter Syndrome?

Iduronidate sulfatase

39

What accumulates in Fabry Disease?

Ceramide trihexoside

40

What accumulates in Gaucher Disease?

Glucocerebroside

41

What accumulates in Niemann-Pick Disease?

Sphingomyelin

42

What accumulates in Tay-Sachs Disease?

GM2 ganglioside

43

What accumulates in Krabbe Disease?

Galactocerebroside

44

What accumulates in Metachromic Leukodystrophy?

Cerebroside sulfate

45

What accumulates in Hunter/Hurler Syndromes?

Dermatan sulfate, heparan sulfate

46

Lipoprotein B-48 is characteristic of which particle?

Chylomicrons

47

Lipoprotein B-100 is characteristic of which particle?

VLDL/IDL/LDL (binds LDL receptor)