Carcinogenesis Flashcards Preview

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Flashcards in Carcinogenesis Deck (41):
1

Which tumor is implicated? BCR-ABL (2)

CML, ALL

2

Which tumor is implicated? BCL-2 (Anti-apoptotic factor)

Follicular lymphoma

3

Which tumor is implicated? BRAF (Ser/Thr kinase) (2)

Melanoma, Non-Hodgkin lymphoma

4

Which tumor is implicated? c-kit (cytokine receptor)

GIST

5

Which tumor is implicated? c-myc (transcription factor)

Burkitt lymphoma

6

Which tumor is implicated? Her2/neu (Epidermal Growth Factor Receptor/Tyrosine Kinase) (3)

Breast, ovarian, gastric carcinoma

7

Which tumor is implicated? L-myc (Transcription factor)

Small cell carcinoma

8

Which tumor is implicated? N-myc (Transcription factor)

Neuroblastoma

9

Which tumor is implicated? RET (Tyrosine Kinase)

Medullary Thyroid Cancer (MEN2A/MEN2B)

10

Which tumor is implicated? APC

Colorectal cancer

11

Which tumor is implicated? BRCA1/2 (DNA repair)

Breast/Ovarian cancers

12

Which tumor is implicated? DCC

Colon Cancer

13

Which tumor is implicated? DPC4/SMAD4

Pancreatic Cancer

14

Which tumor is implicated? Neurofibromin Mutation

NF1

15

Which tumor is implicated? Merlin protein Mutation

NF2

16

Which tumor is implicated? p16 (CDK inhibitor 2A)

Melanoma

17

Which tumor is implicated? Rb (Inhibits E2F) (2)

Retinoblastoma, osteosarcoma

18

Which tumor is implicated? TSC1 (hamartin), TSC2 (Tuberin)

Tuberous Sclerosis

19

Which tumor is implicated? VHL (inhibits hypoxia inducible factor 1A)

Von Hippel Lindau, Renal cell carcinoma

20

Which tumor is implicated? Cyclin D1

Mantle Cell Lymphoma

21

Which tumor is implicated? CDK4

Melanoma

22

Which tumor is implicated? Elevated alpha-fetoprotein (3)

Hepatocellular carcinoma, Hepatoblastoma, Yolk sac tumor

23

Which tumor is implicated? Elevate Beta-hCG (3)

Hydatidiform mole, choriocarcinoma, testicular cancer

24

Which tumor is implicated? CA 15-3, CA27-29

Breast cancer

25

Which tumor is implicated? CA 19-9

Pancreatic adenocarcinoma

26

Which tumor is implicated? CA125

Ovarian cancer

27

Which tumor is implicated? Calcitonin

Medullary thyroid carcinoma

28

Which tumor is implicated? Chromogranin (2)

Neuroendocrine tumors, small cell carcinoma

29

Which tumor is implicated? S-100 (3)

Melanoma, Schwannoma, Langerhans Cell Histiocytosis

30

Which tumor is implicated? Aflatoxins

Hepatocellular carcinoma

31

Which tumor is implicated? Alkylating Agents

Leukemia/Lymphoma

32

Which tumor is implicated? Aromatic amines (esp. derived from cigarette smoke)

Transitional cell carcinoma

33

Which tumor is implicated? Arsenic (3)

Angiosarcoma (liver), lung cancer, squamous cell carcinoma (skin)

34

Which tumor is implicated? Nitrosamines

Gastric cancer (Intestinal type)

35

Which tumor is implicated? Radon

Lung cancer

36

Vinyl chloride

Angiosarcoma (liver)

37

Name possible paraneoplastic syndromes: Lymphoma

Vitamin D

38

Name possible paraneoplastic syndromes: Small cell lung carcinoma

ACTH, ADH, Lamber-Eaton Myasthenic Syndrome

39

Name possible paraneoplastic syndromes: Renal cell carcinoma

ACTH, PTHrP

40

Name possible paraneoplastic syndromes: Hemangioblastoma, hepatocellular carcinoma, leiomyoma, pheochromocytoma

EPO

41

Name possible paraneoplastic syndromes: Breast cancer

PTHrP