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Flashcards in Immunology Deck (32):
1

Name the associated HLA allele: Hemochromatosis

A3

2

Name the associated HLA allele: Psoriatic arthritis

B27

3

Name the associated HLA allele: Ankylosing spondylitis

B27

4

Name the associated HLA allele: Inflammatory Bowel Disease

B27

5

Name the associated HLA allele: Reactive arthritis (Reiter Syndrome)

B27

6

Name the associated HLA allele: Celiac Disease

DQ2/DQ8

7

Name the associated HLA allele: Multiple sclerosis

DR2

8

Name the associated HLA allele: SLE

DR2, DR3

9

Name the associated HLA allele: Goodpasture Syndrome

DR2

10

Name the associated HLA allele: DM Type I

DR3, DR4

11

Name the associated HLA allele: Graves Disease

DR3

12

Name the associated HLA allele: Hashimoto Thyroiditis

DR3, DR5

13

Name the associated HLA allele: Rheumatoid arthritis

DR4

14

Name the associated HLA allele: Pernicious anemia

DR5

15

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th1 cell?

IL-12

16

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th2 cell?

IL-4

17

Which stimulus promotes differentiation of an undifferentiated Th cell into a Th17 cell?

TGF-Beta, IL-6

18

AIRE plays a key role in ______ selection in the thymus.

Negative

19

Name the stimulus for Th1 cell activation.

IFN-gamma, IL-12

20

Name the stimulus for Th2 cell activation.

IL-4

21

What is secreted by Th1 cells?

IFN-gamma

22

What is secreted by Th2 cells?

IL-4, IL-5, IL-10, IL-13

23

What is secreted by macrophages?

IL-12

24

What proteins are released by CTLs when they stimulate apoptosis in infected cells?

Perforin, Granzyme

25

What is secreted by Treg cells?

IL-10, TGF-Beta

26

What is the costimulatory signal for T-cell activation?

B7 (dendritic cell) and CD28 (T-cell)

27

What is the costimulatory signal for B-cell activation?

CD40 (B cell) and CD40L (Th cell)

28

What enzyme mediates somatic hypermutation in B cells?

Terminal deoxynucleotidyltransferase

29

Which Ig isotype? most abundant in serum

IgG

30

Which Ig isotype? Does not fix complement

IgA

31

Which Ig isotype? Most produced antibody

IgA

32

Which Ig isotype? binds mast cells and basophils

IgE