Biologic DMARD Flashcards Preview

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Flashcards in Biologic DMARD Deck (24):
1

Etanercept Class

Biologic DMARD

2

Etanercept MOA

TNF alpha-blocker

3

Etanercept Indication

1. aggressive RA
2. non-responsive to NB-DMARDs

4

Etanercept SE

1. reactivation of hepatitis
2. TB
3. lymphoma

5

Etanercept Contra

1. live vaccines
2. demyelinating disorders
3. HF

6

Etanercept dx-dx

echinacea decrease effect

7

Etanercept other

NOT with anakinra
-1-4 weeks to improvement

8

Abatacept Class

Biologic DMARD

9

Abatacept MOA

inhibits T cells by binding CD80, CD86 on APC

10

Abatacept Indication

RA not responding to DMARDs

11

Abatacept SE

1. HTN
2. Infection

12

Abatacept Other

1. false elevated BS (on day of infusion)
2. decreased effectivenss of dead viruses
3. IV INFUSION ONLY

13

Rituximab Class

B-DMARD: monoclonal antibody

14

Rituximab MOA

reduces inflammation by inhibiting B cells (CD20)

15

Rituximab Indications

1. severe RA in COMBO WITH MTX when TNF agents inadequate
2. lymphocytic leukemia
3. non-Hodgkins lymphoma
4. Wegners Granulomatosis

16

Rituximab SE

1. rash w/infusion
2. edema/htn
3. cytopenia

17

Rituximab prescreen

1. hep B/C
2. TB
3. HIV

18

Rituximab monitor

1. CD20
2. cardiac during infusion

19

Anakinra Class

Biologic DMARD

20

Anakinra MOA

naturally occuring antagonist of IL-1

21

Anakinra Indication

RA unresponsive to one or more DMARDs

22

Anakinra SE

1. infection (38%)
2. injection site rxn
3. neutropenia (decreased WBC)

23

Anakinra dx-dx

lots!!

24

Anakinra other

CAN be used with NB-DMARD