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Flashcards in Gout Meds Deck (24):
1

Colchicine Class

Leukocyte migration inhibitor

2

Colchicine MOA

Inhibits leukocyte migration, phagocytic activity

3

Colchicine Indication

acute gout

4

Colchicine SE

1. myopathy
2. bone marrow suppression

5

Colchicine Contra

1. CKD
2. hepatic disease

6

Colchicine Other

for people who can't use NSAIDs
low therapeutic index

7

Probenacid Class

Uricosurics

8

Probenacid MOA

blocks PCT reabsorption of uric acid

9

Probenacid SE

1. hepatic toxicity
2. nephtolithiasis

10

Probenacid Contra

1. h/o uric acid stones
2. neuropathy
3. egfr

11

Probenacid dx-dx

1. NSAIDs
2. increases abx

12

Probenacid other

1. counteracted by ASA
2. 5-12 months to decrease gout attacks

13

Allopurinol Class

Xanthine Oxidase Inhibitor

14

Allopurinol MOA

Inhibits xanthine oxidase, blocks uric acid formation

15

Allopurinol Indication

gout prophylaxis

16

Allopurinol SE

1. Stevens-Johnson
2. Hypersensitivty syndrome
3. decrease bone marrow

17

Allopurinol dx-dx

1. theophylline
2. warfarin

18

Allopurinol other

1. long t1/2, accumulates in CKD
2. NOT for acute
3. rash w/ampicillin/amoxicillin
4. don't treat non-sxs hyperurcemia

19

Febuxostat Class

Nonpurine, Xanthine Oxidase

20

Febuxostat MOA

selectively inhibits xanthine to decrease uric acid production

21

Febuxostat Indication

management of hyperurcemia in gout

22

Febuxostat SE

1. liver fxn
2. arthralgia

23

Febuxostat dx-dx

1. increase azathioprine, theophylline

24

Febuxostate Other

use NSAID or colchine as bridge for first 6 months