bleeding Flashcards
what is factor I
fibrinogen
what is factor II
prothrombin
what clotting factor protein that is never made In liver
vWF
where is factor V made
liver and megakaryocytes
where is factor 8 made
liver and endothelial cells
where is factor 13 made
liver and macrophages
where is VWF made
endothelial cells and megacaryocytes
all clotting factors are low in infants except these 3
fibrinogen, factor 8, vWF
what factor has the shortest half life
7
what factor hast he longest half life
13
components fo teh contact activation system
HMW kiniogen, prekallikrein, factor 12 and factor 11
what is in platelet alpha granules
proteins- vWF, factor V, fibrinogen
what is the vWF receptor on platelets and disease if you’re missing it
gp1b-9-5 this is the disease is Bernard soulier
what is the fibrinogen receptor on platelets and disease if this is missing
gp1b/2a- disease is glanzmans
thrombin has a direct effect on 6 coag factors. name them
activates 8 to 8a, V to Va, 11 to 11a, fibrinogen to fibrin and then 13 to 13a and TAFI to TAFI a (last two are antifibrionolytic)
what factor cross links fibrin
13
what does thrombin do to platelet
activates them
what does thrombomodulin + thrombin do
activates protein C
what does protein C do
inhibits Va and 8a
what does antithrombin do
inhibits thrombin and 10ah
what does protein S do
protein c needs protein S to inhibit 5a and8a
what is PAI1
plasminogen activator inhibitor type 1- inhibits TPA
what does TPA do
plasminogen into plasmin
what is thrombin time testing
fibrinogen to fibrin via thrombin
