survivorship

Question 1

Teens- inferior BALL- biology reasons

Answer 1

more likely to be PH+ or Ph like and less likely to have ETV6-RUNX1 or hyperdiploidy

Question 2

Teens- inferior TALL- biology reason

Answer 2

more likely to have HOX+

Question 3

Rhabdomyosarcoma- AYA- biology for worse outcomes

Answer 3

more likely to be alveolar

Question 4

Teens bad biology breast cancer

Answer 4

more likely triple negativet

Question 5

teens colorectal cancer bad biology

Answer 5

more likely mucinous adenocarcinoma

Question 6

Teens better biology- DLZBCL

Answer 6

less likely to have t(14;18)

Question 7

Teens better biology melanoma

Answer 7

morel likely BRAF mutation

Question 8

teens better ependymoma

Answer 8

better supgroups and more likely in spinal

Question 9

three pediatric diseases where treating on peds protocols has better outcomes

Answer 9

ALL, rhabdomyosarcoma, Ewings

Question 10

Compare myelosuppresison for AYA vs peds

Answer 10

less in AYA

Question 11

When does radiation induced neurocognitive sequelae happen

Answer 11

1-2 years after radiation. progressive because of failure or slow rate of learning new skills but not progressive loss

Question 12

what chemo drugs cause neurocognitive issues

Answer 12

HD and IT MTX, HD cytarabine

Question 13

what is the most common and first anterior pituitary problem to happen

Answer 13

Growth hormone deficiency

Question 14

3 most common diseases represent in childhood cancer survivors

Answer 14

ALL, Hodgkins, brain tumors

Question 15

Acute cardiotoxicity from anthracyclines- timeline, prognosis

Answer 15

`within 1 week, reversible usuallychr

Question 16

anthracycline dose with higher risk of cardiomyopathy

Answer 16

more than 250mg/m2

Question 17

radiation dose associated with cardiomyopathy

Answer 17

chest XRT more than 30Gy or 15Gy + anthracyclines

Question 18

most common cause of cardiac death after XRT

Answer 18

ischemic heart disease from coronary artery disease

Question 19

which chemo cause proximal tubular dysfunciton

Answer 19

ifosfamide

Question 20

which chemo causes glomerular and distal tubular dysfunction in kids

Answer 20

cisplatin

Question 21

which steroid has a higher risk for AVN

Answer 21

dexamethasone more than prednisone

Question 22

2 DRUGDS THAT CAUSE OSTEOPENIA

Answer 22

METHOTREXATE AND STEROIDS

Question 23

what do platinum drugs do to hearing

Answer 23

destroy cochlear hair cells causing sensorineural hearing loss. high frequency goes first

Question 24

most common thyroid late effect

Answer 24

hypothyroidism

Question 25

leading cause of non oncologic death in childhood cancer survivors

Answer 25

cardiac

Question 26

what kind of problems do anthracyclines cause with the heart

Answer 26

systolic dysfunction

Question 27

Compare doxo, daunt, mitoxantrome, epirubicin, and idrabuciin in terms of toxic to the heart. Rank from lower to highest

Answer 27

Lowest- Dauno, then Epirubicin, Doxo, Idarubicin, Mitoxantrone

Question 28

subsequent T-MDS/AML- timeline

Answer 28

<3 years, plateaus 10-15 years

Question 29

subsequent T-MDS/AML- timeline. Category that is sooner-- give drug, translocation, and timeline

Answer 29

Topoisomerase II inhibitors- (including anthracyclines)- 11q23, 6mo-3 yaers

Question 30

subsequent T-MDS/AML- category of later- give drugs, translocation, and timeline

Answer 30

alkylating agent- preceded by MDS, associated with Chromosome 5-/7-, typically 3-7 years

Question 31

most subsequent malignant neoplasm category

Answer 31

solid tumor

Question 32

WHO IS At higher risk of gonadal toxicity- M or F

Answer 32

M

Question 33

What gonadotoxicity do men get more

Answer 33

Leydig (secrete testosterone)- resistant but sertoliegerm cells are sensitive