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Flashcards in Bleeding disorders Deck (14):
1

what are the 4 main things which will prevent the formation of the platelet plug?

vascular problems
reduced number of platelets
poor platelet function
von willebrand factor deficiency

2

name some vascular causes of the prevention of the formation of the platelet plug

vasculitis- henoch-schonlein purpura,
connective tissue disease- marfans
scurvy
steroids

3

name some causes of reduced number of platelets preventing the formation of the platelet plug

bone marrow failure
disseminated intravascular coagulation
autoimmune thrombocytopenic puprura
hypersplenism

4

name some things which can affect platelet function

drugs such as aspirin, NSAIDS

renal failure

5

what are the main 2 headings which things come under which prevent the formation of the fibrin clot

multiple clotting factor deficiency

single clotting factor deficiency

6

name some causes of multiple clotting factor deficiency

live failure ( as clotting factors are made in the liver)
vit K deficiency
warfarin therapy
disseminated intravascular coagulation

7

what is disseminated intravascular coagulation

excessive and inappropriate activation of haemostatic system

8

what can cause vit K deficiency

poor diet

malabsoprtion- need bile salts
obstructive jaundice- wont produce bile salts
warfarin
haemorrhagic disease of newborn

9

what can cause disseminated intravascular coagulation

sepsis
obstetric emergencies
malignancy
hypovolaemic shock

10

what tests do you do to test fibrin clot formation

PT and APTT

11

name a cause of single clotting factor deficiency

haemophilia

12

deficiency of VIII

haemophilia A

13

deficiency of IX

haemophilia B ( christmas disease)

14

clinical features of haemophilai

recurrent haemarthrosis

recurrent soft tissue bleeds
prolonged bleeding after dental extractions

increased APTT only