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Flashcards in iron Deck (13):
1

why do we need iron

essential fro O2 and electron transport

2

why is iron dangerois

toxic as can generate free radicals

3

what state is iron in a Hb molecule

Fe2+

4

circulating iron is bound to?

transferrin

5

iron is stored as what and where

ferritin

mainly in the liver

6

how to test functional iron

Hb

7

how to test transport iron

transferrin saturation %

8

howto test storage iron

serum ferritin

9

what are the causes of iron deficiency

not eating enoguh- vegan, pregnant

losing blood- GI ulcer, tumour, NSAIDS, haematuria, menorrhagia

not absorbing - coeliac disease

10

where is iron absorbed

duodenum!!

11

what is the role of hepcidin?

it is produced in liver in response to iron overload so it a negative regualtor of iron uptake

12

long term excess iron absorption

primary iron overload
( haemochromatosis)

13

what can cause seocndary iron overload?

repeated blood transfusion

thalassaemia syndroms

sideroblastic anaemias

myelodysplasia