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Flashcards in Blood Clots Deck (22):
1

3 steps of clot formation

vessel constriction, platelet adhesion, cross linking of fibrin through coagulation cascade

2

Prostaglandin F 2a and Thromboxane A2 are what?

Potent vasoconstrictors-helps limit hemorrhage

3

ADP and Serotonin are involved in what?

platelet aggregation

4

coagulation cascade is intitiated by what?

TF binding with factor VII which activates it to VIIa

5

Is intrinsic or extrinsic pathway more important?

extrinsic

6

cascade ultimately leads to

Thrombin which activates Factor XIII that cross links the fibrin mesh

7

small protein that is a serine protease inhibitor-inactivates coagulation

Antithrombin

8

Protein C zymogen is activated when it

binds to thrombin

9

single chain polypeptide which can reversibly inhibit factor Xa

Tissue factor pathway inhibitor

10

which protein cuts fibrin to help break down clots?

plasmin

11

Streptokinase, urokinase, reteplase, alteplase, tenecteplase are all

fibrinolytics-used to break down thrombi

12

these drugs act on antithrombin

indirect thrombin inhibitors-heparin

13

Fondaparinux works exactly like____

Heparin-binds to AT

14

Drugs that act on anti-thrombin are considered what?

indirect inhibitors

15

Drugs that act on fibrinogen and block its activity are considered

direct thrombin inhibitors

16

Coumarins (anti coagulant) works by what mechanism?

Blocks the conversion of oxidized vitamin K back to the reduced form. The body then runs out of reduced vitamin K and thrombin becomes inactive.

17

antidote for warfarin overdose

vitamin K, aqua mephyton

18

Antidote for heparin overdose

protamine sulfate

19

Aspirin inhibits what?

thromboxane A2 synthesis

20

Clopidogrel works by blocking what?

ADP receptors

21

Epifbatide and tirofiban work by blocking what?

GPIIb/IIIa

22

Bleeding disorders are treated by what?

replacement therapy