Flashcards in Blood Clots Deck (22):
3 steps of clot formation
vessel constriction, platelet adhesion, cross linking of fibrin through coagulation cascade
Prostaglandin F 2a and Thromboxane A2 are what?
Potent vasoconstrictors-helps limit hemorrhage
ADP and Serotonin are involved in what?
coagulation cascade is intitiated by what?
TF binding with factor VII which activates it to VIIa
Is intrinsic or extrinsic pathway more important?
cascade ultimately leads to
Thrombin which activates Factor XIII that cross links the fibrin mesh
small protein that is a serine protease inhibitor-inactivates coagulation
Protein C zymogen is activated when it
binds to thrombin
single chain polypeptide which can reversibly inhibit factor Xa
Tissue factor pathway inhibitor
which protein cuts fibrin to help break down clots?
Streptokinase, urokinase, reteplase, alteplase, tenecteplase are all
fibrinolytics-used to break down thrombi
these drugs act on antithrombin
indirect thrombin inhibitors-heparin
Fondaparinux works exactly like____
Heparin-binds to AT
Drugs that act on anti-thrombin are considered what?
Drugs that act on fibrinogen and block its activity are considered
direct thrombin inhibitors
Coumarins (anti coagulant) works by what mechanism?
Blocks the conversion of oxidized vitamin K back to the reduced form. The body then runs out of reduced vitamin K and thrombin becomes inactive.
antidote for warfarin overdose
vitamin K, aqua mephyton
Antidote for heparin overdose
Aspirin inhibits what?
thromboxane A2 synthesis
Clopidogrel works by blocking what?
Epifbatide and tirofiban work by blocking what?