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Flashcards in Diuretics Deck (28):
1

What ion does water follow in the kidneys?

Sodium

2

what does carbonic anhydrase do in the kidneys?

Brings Na and HCO3 back into the blood- brings water out of urine into blood-results in higher blood pressure

3

Carbonic anhydrase inhibitors do what?

keep water from being reabsorbed and decreases blood pressure

4

Osmotic diuretics work how?

fill the urine with substances, makes water follow it-to the urine and increases urine output

5

osmotic diuretics are given how?

Intravenously

6

loop diuretics block what?

transporter that resorbs sodium and chloride. Results in increased urine output

7

Where do loop diuretics take action?

in the ascending loop of Henle

8

What are some diuretics that are high allergy drugs?

Sulfonamides (which are loop diuretics)

9

Thiazide diuretics take place where?

In the distal convoluted tubule

10

Thiazide diuretics work on what?

Symporter of NaCl

11

Thiazide and loop diuretics affect which ion that needs to be monitored?

potassium

12

K+ sparing diuretics work how

Na channel that brings Na back into blood OR antagonist of the aldosterone receptor.

13

Which diuretics are used as adjunctive therapy?

Potassium sparing diuretics

14

systolic is the higher/lower number

higher

15

diastolic number is the higher/lower number

lower

16

sympathetic nerves adjust what to regulate vasoconstriction, heart beat and cardiac output/

Catacholamines

17

what enzyme cuts angiotensinogen?

Renin

18

What converts angiotensin 1 to angiotensin II?

ACE

19

angiotensin results in?

Increases blood pressure

20

angiotensin acts on the adrenal gland to release what?

Aldosterone

21

4 types of drugs to treat hypertension

1. diuretics
2. Sympathoplegic agents
3. direct vasodilators
4. block angiotensin II production or activity

22

thiazide diuretics are used for

mild to moderate hypertension

23

sympathoplegic agents activate which receptor?

a2 recepotrs in the CNS-reduce cardiac output; reduce release of epinephrine from sympathetic nerve endings

24

block B1 receptors

no longer the most popular way to treat high BP, they diminish cardiac output and diminish renin production

25

4 kinds of vasodilators

nitric oxide, reduce Ca influx to smooth muscle, hyperpolarization of smooth muscle, activation of dopamine receptors

26

ACE inhibitors work on ?

inhibition of formation of angiotensin II (also degrade bradykinin)

27

pril ending means a drug is a what?

ACE inhibitor

28

sartan or saran suffix means what type of drug?

block AT1 receptor-