clot
a red gelatonous mass
where do clots form and why do they form there?
they for in the vein/capillaries/small arterioles because pressure of the blood flow blows out clot in large arteries
prothrombin
inactive form of thrombin- activated when needed
extrinsic pathway
tissue damage caused release of tissue factor which activates factor then 10 then prothrombin to thrombin
intrinsic pathway
damage to the exposed endothelial surface this activates a cascade leading to factor X (exposing underlying endothelial surface) to factor 10 which converts prothrombin to thrombin
similarities between intrinsic and extrinsic pathways
turns prothrombin into thrombin
chelating agents
removes calcium from the blood. this removes one of the factors which means no clot add back in the calcium and you can determine clot times and factor deficiencies
Collagen exposed
VWF binds to tisse and begins cascade
role of platelets
get trapped to VWF, then factor 7 attaches, platelets will accumulate
platelet plug
made fast and controls the whole coagulation response