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BLOODBANK/IMMUNOHEMATOLOGY > Blood Preservation and Banking > Flashcards

Blood Preservation and Banking Flashcards

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1
Q

Blood collection or exposure to air through an open port.

A

Open system

shortens expiration due to potential bacterial contamination

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2
Q

Crucial areas for normal erythrocyte survival and function.

A

Normal RBC membrane composition and structure, Hemoglobin structure and function, RBC metabolism.

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3
Q

Goal of blood preservation.

A

Provide viable and functional blood components for transfusion.

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4
Q

FDA requirement for post-transfusion RBC survival.

A

Average 24-hour post-transfusion RBC survival must be more than 75%.

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5
Q

Chelates calcium to prevent coagulation

A

Citrate/Sodium Citrate

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6
Q

Maintains pH and adequate levels of 2,3-DPG

A

Phosphate buffer/Sodium diphosphate

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7
Q

Sugar to support RBC life and ATP production

A

Dextrose

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8
Q

Used in ATP synthesis, extends shelf-life from 21 to 35 days

A

Adenine

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9
Q

Decreased RBC storage lesion effect on RBCs.

A

Decreased % viable cells, Glucose, ATP, pH, 2-3 DPG.

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10
Q

Increased microaggregate effects in RBC storage.

A

Increased lactic acid, Plasma K+, Plasma hemoglobin.

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11
Q

Oxyhemoglobin-dissociation curve shift in RBC storage lesions.

A

Shift to the left, increase hemoglobin affinity for O2, decreased O2 delivery to tissues.

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12
Q

Acid citrate dextrose (ACD) storage

A

21 days storage period

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13
Q

Citrate phosphate dextrose (CPD) storage

A

21 days storage period

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14
Q

Citrate phosphate double dextrose (CP2D) storage

A

21 days storage period

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15
Q

Citrate phosphate dextrose adenine-2 (CPDA-2) storage

A

35 days storage period

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16
Q

Citrate phosphate dextrose adenine-1 (CPDA-1) storage (most common)

A

35 days storage period

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17
Q

Additive content in AS-1.

A

ADSOL (AS-1) - SALINE, ADENINE, GLUCOSE, MANNITOL

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18
Q

Additive content in AS-3.

A

NUTRICEL (AS-3) - SALINE, ADENINE, CITRATE, PHOSPHATE

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19
Q

Additive content in AS-5.

A

OPTISOL (AS-5) - SALINE, ADENINE, MANNITOL

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20
Q

Additive content in AS-7.

A

SOLX (AS-7) - SALINE, ADENINE, MANNITOL

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21
Q

Storage period for blood stored with AS-1, AS-3, AS-5, AS-7 additives.

A

42 DAYS

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22
Q

Sedimenting agent for WBC separation

A

Hydroxyethyl Starch (HES)

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23
Q

Corticosteroids (Prednisone or Dexamethasone) / Growth factors function

A

Increase circulating RBC

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24
Q

Male (FDA Double RBCs) requirement

A

130 lbs minimum, 5’1’’ height

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25
Female (FDA Double RBCs) requirement
150 lbs minimum, 5'5'' height
26
Hematocrit (FDA Double RBCs) requirement
>40%
27
Single donor platelets (Whole blood)
Plateletpheresis
28
Apheresis is standard and acceptable, either as primary therapy or as a first-line adjunct to other initial therapies.
Category I
29
Apheresis is generally accepted in a supportive role or as second-line therapy, rather than first-line therapy.
Category II
30
Apheresis is not clearly indicated based on insufficient evidence, conflicting results, or inability to document a favorable risk-to-benefit ratio.
Category III
31
Apheresis has been demonstrated to lack efficacy or be harmful and should be discouraged in these disorders.
Category IV
32
FDA-recognized blood labeling languages.
ABC Codabar, ISBT 128
33
Blood label color indication for Blood Type A.
YELLOW
34
Blood label color indication for Blood Type B.
PINK
35
Blood label color indication for Blood Type AB.
WHITE
36
Blood label color indication for Blood Type O.
BLUE
37
Blood label color for hold for further processing.
TAN
38
Blood label color for emergency use only.
ORANGE
39
Blood label color for autologous use only.
GREEN
40
Blood label color for not for transfusion.
GRAY
41
Blood label color for irradiated blood.
PURPLE
42
Blood label color for biohazard indication.
RED
43
Blood label color for therapeutic phlebotomy.
CHARTREUSE (YELLOW GREEN)
44
Information found in the top left quadrant of the blood component label.
Donation and collection facility identifiers
45
Information found in the bottom left quadrant of the blood component label.
Product description
46
Information found in the top right quadrant of the blood component label.
Blood type
47
Information found in the bottom right quadrant of the blood component label.
Expiration date and special labels
48
Purpose of rejuvenation solutions.
Used to regenerate adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (2,3-DPG) in red cells.
49
Storage and rejuvenation process for red cells.
Red cells stored for fewer than 3 days after outdate are rejuvenated for 1-4 hours at 37°C with rejuvenation solution.
50
Components of rejuvenation solutions (PIGPA,PIPA).
PIGPA: phosphate, inosine, glucose, pyruvate, adenine; PIPA: phosphate, inosine, pyruvate, adenine.
51
FDA-approved rejuvenation solution in the US.
Rejuvesol.
52
Whole blood submission for storage at 1-6°C.
Submit within 24 hours.
53
Whole blood submission for storage at 20-24°C.
Submit within 6 hours.
54
Whole blood for platelet preparation (CPDA within 8 hours, ACD within 6 hours).
Submit within 6-8 hours after collection.
55
Donor blood unit processing.
All donor units are processed before being released for compatibility testing and transfusion.
56
Shelf life of packed red blood cells (PRBCs)
Same as whole blood in a closed and open system.
57
Storage temperature for PRBCs
1–6°C.
58
Maximum hematocrit for PRBCs
80% or less.
59
Indication for PRBCs
Restores oxygen-carrying capacity in anemia.
60
Shelf life of leukopoor RBCs in a closed system
Same as PRBCs.
61
Shelf life of leukopoor RBCs in an open system
24 hours.
62
Storage temperature for leukopoor RBCs
1–6°C.
63
Residual WBC content in leukopoor RBCs
5 x 10^6.
64
Shelf life of washed RBCs in an open system
24 hours.
65
Storage temperature for washed RBCs
1–6°C.
66
QC requirement for washed RBCs
Plasma removal.
67
Storage and shipping temperature for whole blood
Storage: 1–6°C; Shipping: 1–10°C.
68
Shelf life of whole blood with CPD or CP2D preservatives
21 days.
69
Shelf life of whole blood with CPDA-1 preservative
35 days.
70
Storage and shipping temperature for RBCs
Storage: 1–6°C; Shipping: 1–10°C.
71
Shelf life of RBCs in CPD, CP2D, or CPDA-1
CPD/CP2D: 21 days; CPDA-1: 35 days.
72
Shelf life of RBCs with AS-1, AS-3, AS-5, or AS-7 solutions
42 days.
73
Hematocrit limit for CPDA-1 RBC units
≤80%.
74
Storage temperature and duration for frozen RBCs
≤-65°C; 10 years.
75
Storage temperature and duration for deglycerolized or washed RBCs (open system)
1–6°C; 24 hours.
76
QC requirement for deglycerolized or washed RBCs
Visual hemoglobin check; method ensuring ≥80% RBC recovery.
77
Shelf life of irradiated RBCs
28 days from irradiation or original outdate, whichever is first.
78
Irradiator QC for irradiated RBCs
25 Gy in center of the unit.
79
Storage temperature and residual WBC limit for leukocyte-reduced RBCs
1–6°C; <5.0 x 10^6 residual leukocytes with ≥85% original cells retained.
80
Storage temperature and shelf life of PF24 plasma
≤-18°C; 1 year.
81
Storage temperature and shelf life of FFP
≤-18°C: 1 year; ≤-65°C: 7 years.
82
Shelf life of thawed PF24 or FFP
1–6°C; 24 hours.
83
Shelf life of thawed plasma
1–6°C; 5 days (not FDA-licensed).
84
Storage temperature and shelf life for cryoprecipitated AHF
≤-18°C; 1 year.
85
QC requirements for cryoprecipitated AHF
Factor VIII: ≥80 IU; Fibrinogen: ≥150 mg.
86
Storage temperature and shelf life for pooled cryoprecipitate after thawing
20–24°C; 4 hours.
87
QC requirements for pooled cryoprecipitate
Factor VIII: ≥80 IU and Fibrinogen: ≥150 mg times the number of units in the pool.
88
Storage conditions and shelf life for platelets
20–24°C with constant agitation; 5 days.
89
QC requirements for platelets
≥5.5 x 10^10 platelets in 90% of units; pH ≥6.2.
90
Storage conditions and shelf life for pooled platelets (open system)
20–24°C with constant agitation; 4 hours.
91
Storage conditions for apheresis platelets leukocyte-reduced
20–24°C with constant agitation.
92
Shelf life for apheresis platelets leukocyte-reduced (open system)
Within 4 hours.
93
Shelf life for apheresis platelets leukocyte-reduced (closed system)
5 days.
94
QC requirements for apheresis platelets leukocyte-reduced
<5.0 x 10^4 residual leukocytes in 95% of units; ≥3.0 x 10^11 platelets in 90% of units; pH ≥6.2.
95
Storage temperature and shelf life for apheresis granulocytes
20–24°C; 24 hours.
96
QC requirements for apheresis granulocytes
≥1.0 x 10^10 granulocytes in 75% of units.

BLOODBANK/IMMUNOHEMATOLOGY (22 decks)

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