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Flashcards in Blood products and transfusion Deck (98)
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1

Available products for transfusion (5)

Red blood cells
Platelets
Coagulation products
Cryoprecipitate
Factor concentrates

2

Available products for transfusion (5)

Red blood cells
Platelets
Coagulation products
Cryoprecipitate
Factor concentrates

3

Centrifugation separates blood in to what components

RBC and platelet rich plasma

4

What is FFP

Plasma frozen within 24 hours of collection

5

What is cryoprecipitate

High MW component of FFP is thawed at low temperature

6

When are irradiated blood products used

Immunocomporomised
Chemotherapy
First degree relative
HLA matched products
IU products

7

When is CMV negative blood required (4)

Possible transplant recipients
Neonates
Seronegative pregnant women
AIDS

8

How much is the Hb expected to rise for each unit of pRBC given

Hb rise 10 for each unit (4%)

9

At what Hb would pRBC be indicated

10

During active bleeds what Hb is desirable

>70-100

11

When should Hb be kept higher

CAD/unstable angina
Active/unpredictable bleeds
Impaired pulmonary function
Increased oxygen consumption

12

When pRBC are anticipated, what should be ordered

Group and screen
Cross match

13

What options are available for pRBC transfusion

First line- group and screen, cross match
2. Same group and Rh status
3. O- for females of reproductive age, O+ for males

14

Platelet products available and indications

Pooled random->thrombocytopenia w/ bleeding
Single donor->potential BMT recipients
HLA matched->refractory to pooled or single, presence of HLA antibodies

15

How much does PLT increase from random donor pool and single donor

>15 X 10^9 for pooled
40-60 X 10^9 for single

16

Indications for platelet transfusion at levels

500

17

relative contraindications of PLT transfusion (4)

ITP
TTP
Post-transfusion -ve PLT
HELLP

18

Indications for FFP

Depletion of multiple coag factors
Emergency reversal of life-threatening bleeding secondary to warfarin overdose.

19

Etiology of multiple depleted coagulation factors

Sepsis
DIC
Liver disease
TTP/HUS
Dilution

20

Indications for cryoprecipitate

Factor 8 deficiency
vWF deficiency
Hypofibrinogenemia

21

Causes of immune acute blood transfusion reaction

Acute hemolytic transfusion reaction
Febrile non hemolytic transfusion reactions
Allergic nonhemolytic transfusion
Transfusion related acute lung injury

22

Causes of acute blood transfusion reaction

Acute hemolytic transfusion reaction
Febrile non hemolytic transfusion reactions
Allergic nonhemolytic transfusion
Transfusion related acute lung injury

23

DDX of post-transfusion dyspnea

Circulatory overload
TRALI
Allergy->bronchospasm, anaphylaxis

24

DDX of post-transfusion dyspnea

Circulatory overload
TRALI
Allergy->bronchospasm, anaphylaxis

25

Centrifugation separates blood in to what components

RBC and platelet rich plasma

26

What is FFP

Plasma frozen within 24 hours of collection

27

What is cryoprecipitate

High MW component of FFP is thawed at low temperature

28

When are irradiated blood products used

Immunocomporomised
Chemotherapy
First degree relative
HLA matched products
IU products

29

When is CMV negative blood required (4)

Possible transplant recipients
Neonates
Seronegative pregnant women
AIDS

30

How much is the Hb expected to rise for each unit of pRBC given

Hb rise 10 for each unit (4%)