Flashcards in Blood products and transfusion Deck (98)
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1
Available products for transfusion (5)
Red blood cells
Platelets
Coagulation products
Cryoprecipitate
Factor concentrates
2
Available products for transfusion (5)
Red blood cells
Platelets
Coagulation products
Cryoprecipitate
Factor concentrates
3
Centrifugation separates blood in to what components
RBC and platelet rich plasma
4
What is FFP
Plasma frozen within 24 hours of collection
5
What is cryoprecipitate
High MW component of FFP is thawed at low temperature
6
When are irradiated blood products used
Immunocomporomised
Chemotherapy
First degree relative
HLA matched products
IU products
7
When is CMV negative blood required (4)
Possible transplant recipients
Neonates
Seronegative pregnant women
AIDS
8
How much is the Hb expected to rise for each unit of pRBC given
Hb rise 10 for each unit (4%)
9
At what Hb would pRBC be indicated
10
During active bleeds what Hb is desirable
>70-100
11
When should Hb be kept higher
CAD/unstable angina
Active/unpredictable bleeds
Impaired pulmonary function
Increased oxygen consumption
12
When pRBC are anticipated, what should be ordered
Group and screen
Cross match
13
What options are available for pRBC transfusion
First line- group and screen, cross match
2. Same group and Rh status
3. O- for females of reproductive age, O+ for males
14
Platelet products available and indications
Pooled random->thrombocytopenia w/ bleeding
Single donor->potential BMT recipients
HLA matched->refractory to pooled or single, presence of HLA antibodies
15
How much does PLT increase from random donor pool and single donor
>15 X 10^9 for pooled
40-60 X 10^9 for single
16
Indications for platelet transfusion at levels
500
17
relative contraindications of PLT transfusion (4)
ITP
TTP
Post-transfusion -ve PLT
HELLP
18
Indications for FFP
Depletion of multiple coag factors
Emergency reversal of life-threatening bleeding secondary to warfarin overdose.
19
Etiology of multiple depleted coagulation factors
Sepsis
DIC
Liver disease
TTP/HUS
Dilution
20
Indications for cryoprecipitate
Factor 8 deficiency
vWF deficiency
Hypofibrinogenemia
21
Causes of immune acute blood transfusion reaction
Acute hemolytic transfusion reaction
Febrile non hemolytic transfusion reactions
Allergic nonhemolytic transfusion
Transfusion related acute lung injury
22
Causes of acute blood transfusion reaction
Acute hemolytic transfusion reaction
Febrile non hemolytic transfusion reactions
Allergic nonhemolytic transfusion
Transfusion related acute lung injury
23
DDX of post-transfusion dyspnea
Circulatory overload
TRALI
Allergy->bronchospasm, anaphylaxis
24
DDX of post-transfusion dyspnea
Circulatory overload
TRALI
Allergy->bronchospasm, anaphylaxis
25
Centrifugation separates blood in to what components
RBC and platelet rich plasma
26
What is FFP
Plasma frozen within 24 hours of collection
27
What is cryoprecipitate
High MW component of FFP is thawed at low temperature
28
When are irradiated blood products used
Immunocomporomised
Chemotherapy
First degree relative
HLA matched products
IU products
29
When is CMV negative blood required (4)
Possible transplant recipients
Neonates
Seronegative pregnant women
AIDS
30
