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Flashcards in SIADH Deck (6)
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1

Define

1. Inappropriate secretion from posterior pituitary
2. Ectopic production

2

Pathophysiology

+ADH->excessive reabsorption of water in distal neprhon, not inhibited by hyponatremia.
Plasma osmolality falls

3

Calculate plasma osmolality

2 X sodium + urea + glucose

4

Diagnosis made

Comparison of plasma oxmolality and urine->urine osmolarity inappropriately elevated

5

Drug mechanism

1. +ADH
2. Potentiate effects
3. Unknown mechanism

6

Causes

1. Drugs
AntiD, antipsychotics
Chemotherapy
Omeprazole
2. Post-operative stress
3. CNS
Infections
Stroke
Trauma
Neurosurgery
4. Pulmonary
Pneumonia
TB, empyema
Status asthmaticus
5. Malignant
Neoplasm
Lymphoma
Leukemia
Mesothelium
Ewings sarcoma
6. Psychoses
7. Vasopressin or oxytocin