BM2_MICRO_Q4 Flashcards by My Wallet Is Dead

This is a folinic acid analog whose mechanism of action is inhibition of dihydrofolate reductase. Its primary use is in the treatment of Pneumocystis jirovecii infections in AIDS patients who are intolerant of or refractory to trimethoprim–sulfamethoxazole and pentamidine isethionate. *
Remdesivir
Azithromycin
Trimetrexate
Metronidazole

Trimetrexate

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Cytomegalovirus affects the organs in latent infection except *
Kidneys
Glands
Lymphoid tissue
Neurons

Neurons

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The common name of Human Herpes 8 is *
Epstein-Barr
Herpes Simplex
Kaposi sarcoma
Varicella-zoster

Kaposi sarcoma

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Epstein Barr Virus is a member of what subfamily of the herpesviruses *
All of the above
Gamma
Alpha
Beta

Gamma

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Cytomegalovirus belongs to official name ( Human Herpesvirus) *
5
7
1
3

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Roseola infantum infects what type of lymphocytes? *
T
B
Null
Nk

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Fatal Herpes encephalitis is closely associated with *

Herpes simplex 2
Herpes simplex 1
Epstein-Barr virus

Herpes simplex 1

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Which of the following parts of the body is most commonly affected by Varicella-zoster infection? *
Neck
Head
Trunk
All of the above

Trunk

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Microcephaly is associated in what Herpes virus? *
Cytomegalovirus
Herpes simplex 2
Herpes simplex 1
Roseola infantum

Cytomegalovirus

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Epstein Barr virus is associated with what neoplasm? *
Lymphoma
All of the above
Gastric carcinoma
Nasopharyngeal carcinoma

All of the above

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A marker of past infection and indicates immunity in Epstein Barr virus infection *
Antibodies to Early antigen
VCA IgM
VCA IgG
Heterophile

VCA IgG

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Multinucleated giant cells and intranuclear inclusions in the form of Owl eye appearance are highly specific of what Herpes Virus? *

Cytomegalovirus
Varicella zoster
Kaposi Sarcoma
Herpes simples I

Cytomegalovirus

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A classical picture of this virus is seen in *
Herpes Simplex
Epstein Barr virus
Herpes Simplex 1
Varicella-Zoster

Herpes Simplex

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Kissing disease is associated with what Herpes virus? *
Epstein Barr
Cytomegalovirus
Varicella-zoster
Herpes simplex 1

Epstein Barr

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Which of the following Hepatitis virus lead to chronicity? *
All of the above
A and E
B, C, D
B only

B, C, D

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Ether and acid sensitivity are commonly found in what type of Hepatitis *
C
A and E
B
D

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Fulminant disease is frequent in what type of Hepatitis ? *
D
C
B
A and E

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Oncogenicity is associated with what type of Hepatitis except *
D
B
C
A

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The only Hepatitis having DNA genome *
D
C
A and E
B

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A common etiologic agent of post transfusion hepatitis *
B
D
C
All of the above

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Which of the serologic antibodies in Hepatitis B is patient immune protected especially upon receiving vaccine? *
HBs Ag (+), Anti-HBc and Anti-HBs (-)
HBs Ag, Anti-HBc and Anti-HBs (-)
HBs Ag and Anti-HBc (-), Anti-HBs (+)
HBs Ag and Anti-HBc (+), Anti-HBs (-)

HBs Ag and Anti-HBc (-), Anti-HBs (+)

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This causes infection only in the presence of Hepatitis virus
A
E
B
C

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Possible Hepatitis B infection in remote past *
HBs Ag and Anti-HBs (-), Anti- HBc (+)
HBs Ag and Anti-HBc (+), Anti-HBs (-)
HBs Ag, Anti-HBc and Anti-HBs (-)
HBs Ag (+), Anti-HBc and Anti-HBs (-)

HBs Ag and Anti-HBs (-), Anti- HBc (+)

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Virus vaccines are available against *
All of the above
A and B
A and E
C and D

A and B

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Transmitted by fecal-oral route transmission * All of the above B, C, D A and E B, C

A and E

These causes liver cancer years after infection * B A B and C D

B and C

A member of Ebola with no mortality rate in humans and found in the Philippines * Ivy Coast Reston Zaire Sudan

Reston

Identical to Marburg virus but differ in the antigenecity * Ebola Lassa Crimean Congo Hanta

Ebola

The most lethal human pathogen among Arena virus * Marburg Lassa All of the above Rift valley

Lassa

Which can inactivate Lassa Fever virus * Detergents Gamma radiation UV radiation All of the above

All of the above

An RNA virus of arthropod borne with 3 segments Arena Bunya Flavi Filo

Bunya

The organ with the highest titers of virus is: * Parotid gland skin trauma Submandibular salivary gland Submaxillary salivary gland CNS

Submaxillary salivary gland

Orthomyxoviruses viral transcription occurs in the: * Cytoplasm Ribosomes Cell Nucleus

Nucleus

Reye’s syndrome is associated with what drug? * Paracetamol Amoxicillin Aspirin Mefenamic Acid

Aspirin

The etiologic agent of Bronchiolitis is: * Respiratory syncytial virus Adenovirus Influenza virus Parainfluenza virus

Respiratory syncytial virus

Which of the following is not a nucleic acid based testing for viruses? * Nucleic acid amplification Strand displacement amplification Enzyme immunoassay Polymerase chain reaction

Enzyme immunoassay

Treatment of exposed person to skunks: * Observe the animal Consider immediate prophylaxis Go to animal bite center None

Consider immediate prophylaxis

This causes progressive multifocal leukoencephalopathy, a central nervous system complication that occurs in some immunosuppressed individuals. * Borna virus Hanta virus JC virus Prion

JC virus

Prions are sensitive to which of the following: * Dry heat Phenol Urea Formaldehyde

Phenol

A fatal, degenerative disease affecting the nervous systems of sheep and goats. The disease is characterized by the development of amyloid plaques in the central nervous system of infected animals. * CJD Kuru Gerstmann-Sträussler- Scheinker syndrome Scrapie

Scrapie

A scrapie-like disease, found in mule deer and elk in the United States and Canada, Infectivity has been detected in feces of deer before they become ill; the agent is retained in the soil, where it can then be ingested by other deer and elk. * Chronic wasting disease Scrapie Kuru CJD

Chronic wasting disease

Which of the following are the contents of Viral transport medium (VTM) contains a buffered salt solution, protein and saccharide nutrients, pH indicator, and antibiotics to inhibit bacterial and fungal conta * Protein and saccharide nutrients pH indicator and antibiotics All of the above Buffered salt solution

All of the above

This is linked to Infectious mononucleosis, nasopharyngeal carcinoma and Burkitt's lymphoma * HSV-1 HSV-2 Varicella-Zoster Epstein -Barr virus

Epstein -Barr virus

Epstein Barr Virus attaches to the C3d Receptor (CD21) on the surface * NK B Null T

The only marker of primary congenital infection of Cytomegalovirus * IgE IgG IgA IgM

IgG

During breech delivery, the exposed areas of the baby infected with Herpes simplex are * Chest wall and buttocks Lower extremities Face and scalp Upper extremities

Lower extremities

Complications of genital herpes during pregnancy include * Preterm labor All of the above Severe neonatal infection Amnionitis

All of the above

Non enveloped agents with fecal-oral transmission * B and C B and D All of the above A and E

A and E

The leading cause of non-A non-B hepatitis infection * D B A C

This reflects viral replication in Hepatitis C * DNA IgG RNA IgM

RNA

A flavivirus related to HCV that has been identified in post transfusion hepatitis, does not appear to be hepatotropic, does not replicate efficiently in hepatocytes, and does not cause acute or chronic hepatitis. * Hepatitis B Hepatitis GB virus-C (GBV-C) Hepatitis D Hepatitis C

Hepatitis GB virus-C (GBV-C)

Which one is true about Hepatitis E * Most people recover completely. All of the above Can cause serious illness in pregnant women with mortality reaching 10-30% in the 3rd trimester The overall case-fatality rate is about 1%

All of the above

Mode of transmission of Hepatitis B * Blood transfusion Needle sharing All of the above Occupational injury with contaminated sharp objects

All of the above

Which one is true on the diagnosis of chronic HBV infection? * All of the above Presence of HBV DNA Presence of HBsAg and E antigen Absence of anti-HBc IgM

All of the above

A defective RNA viroid that requires HBV surface antigen for full expression, replication, and transmission. * HEV HAV HCV HDV

HDV

Serologic diagnosis of acute infection of Hepatitis B is based on the following except * Presence of the Hepatitis Antibody All of the above Presence of IgM antibody to hepatitis B core antigen (anti-HBc) Presence of hepatitis B surface antigen (HBsAg) xxx

Presence of the Hepatitis Antibody

Which one is true about Hepatitis A. * Adults occasionally develop severe infection. Acute disease in children is mild and often asymptomatic All of the above IgM antibody is the most practical marker of acute infection

All of the above

Which Hepatitis lead to lytic hepatocyte injury and account for most clinical cases of infectious hepatitis? * All of the above B and D A and E C

All of the above

Which of the following HAV antibody is an evidence for immunity. * M E A G

These are important routes of spread of Hepatitis B * Sexual contact A and B Ingestion of contaminated food and water Household exposure In body fluids

A and B

Which one is true about the vaccination against Hepatitis B * Decrease the incidence of hepatocellular carcinoma All of the above Sequelae are preventable Infection is preventable

All of the above

RNA virus with Sandfly morphology * Bunya Flavi Arena Filo

Bunya

Marburg and Ebola are examples of * Bunya Flavi Filo Arena

Filo

Dengue virus is under the classification of what virus * Flavi Filo Bunya Arena

Flavi

Mode of transmission of arena virus * Bite of ticks Inhalation of excreta of rodents Nosocomial transmission All of the above

Inhalation of excreta of rodents

These are all RNA viruses except * Arena Adeno Bunya Delta

Adeno

RNA viruses that replicate in the nucleus * Delta Influenza and Retro Arena Bunya

Influenza and Retro

Virus causing warts * Parvovirus B19 Human Herpes virus 6 Papillomavirus Herpes simplex

Papillomavirus

Breakbone fever is caused by * Hanta Dengue Chikungunya Ebola

Dengue

Hepatitis A is a * Picornavirus Hepadna Flavivirus Hepevirus

Picornavirus

The most common cause of Mollaret's meningitis * Herpes simplex Adenovirus Cytomegalovirus Varizella-zoster

Herpes simplex

Herpes simplex virus grows well in what type of cell line? * Mink Kung and HeLa Rhabdomyosarcoma, Vero and Hep-2 Human fibroblasts ( WI-38, MRC-5) and Rabbit Kidney All of the above

Human fibroblasts ( WI-38, MRC-5) and Rabbit Kidney

Incubation period of cultures of Herpes simplex from central nervous system, corneal, oral and other sites should be extended for * 3 days 2 weeks 1 day 1 week

2 weeks

Viral respiratory specimens are refrigerated for no longer than * 48 hours 72 hours 1 week 3 days

72 hours

Which among of the specimens is an acceptable specimen for various types of viruses as confirmation of immunohistochemistry (IHC )or a standalone diagnostic test? * Formalin-fixed, paraffin-embedded (FFPE) tissue Ethanol fixed, paraffin embbedded tissue Fresh specimen All of the above

Formalin-fixed, paraffin-embedded (FFPE)

Cary-Blair media transports what type of specimen? * All of the above Stool Urine Respiratory

Stool

Evidence of recent or current infection requires the demonstration of what antibody? * IgM IgA IgD IgG

IgM