Body Fluid Compartments Flashcards Preview

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Flashcards in Body Fluid Compartments Deck (31):
1

What is needed to calculate the osmolarity

Molar conc and num of osmotic active particle

2

What is osmolality

Has units of osmoles/kg of water

3

What is tonicity

Related to its effect on cell volume

4

What is isotonic

Same cell would have no change in cell vol

5

Hypotonic

More
Solution causes an increase in cell vol as water enters the cell could lead to burst or lysis of cell

6

Hypertonic

Less
Solution causes a decrease in cell volume as water leaves the cell

7

Why does the total body water differ in make and females

Woman have more fatty tissue threef ore less lean tissue and less water

8

What are the two water compartments of the total body water

Intracellular - 67%
Extra cellular -33%

9

What does extracellular fluid includes

Plasma - 20%
Interstitial fluid -80%,

10

What is used to determine the volume of specific fluid compartments

Tracers
Used in:
Tbw --> titrated water
Ecf --> inulin
Plasma --> labelelled albumin

11

How is the volume of water calc in container

V(litres) = dose/sample concentration

12

What is insensible loss.

Uncontrollable occurs without realisation
Skin
Lungs

13

What is sensible loss

Can realise is loss
Sweat
Urine
Faeces

14

What is the ionic composition of sodium in the ICF -
And ECF

ICF - 10mM
ECF - 140mM

15

What is the ionic composition of pottasium in the ICF -
And ECF

ICF - 140mM
ECF - 4.5mM

16

What is the ionic composition of chooride in the ICF -
And ECF

ICF - 7mM
ECF - 115mM

17

What is the ionic composition of bicarbonate in the ICF -
And ECF

ICF - 10mM
ECF - 28mM

18

What are the separating membranes between the plasma, interstitial fluid, intracellular fluid

Between plasma and interstitial fluid --> capillary wall
Between interstitial fluid and intracellular fluid --> plasma mem

19

What is a fluid shift

Movement of water between ICF and ECF in repsonse to an osmotic gradient

20

What does the gain or loss of water do to fluid homeostasis

Change in fluid osmolarity similar changes in ICF and ECF volumes

21

What dos gain or loss of Nacl do to the fluid homeostasis

Change in osmolarity
(a) sodium excluded from ICF
(b) osmotic water movements
These two factors combine to produce opposite changes in ICF and ECF

22

What does gain or loss of isotonic fluid do to the fluid homeostasis

No change in fluid osmolarity change in ECF volume only

23

What does the kidneys do to the ECF

Alter composition and volume which affects blood pressure

24

What do electrolytes do in solution

Dissociate into free ions in solution.

25

Why is it port any to maintain electrolyte balance

Total electrolyte concs can directly affect water balance
The concs of individual electrolytes can affect cell functions

26

Why are sodium and pottasium particularly important

Major contributors to osmotic concentrations of ECF and ICF
Directly affect functioning of all cells

27

What is the balance of sodium in the ECF represent a balance between what two factors

Input of sodium form diet and output excreted in urine

28

Sodium is present where which means what

Mainly present in ECF meaning it is a major determinant of ECF volume

29

Why is minor fluctuations of pottasium bad for the cell

Pottasium is imp to establish resting membrane potential in cells and resting membrane potential

30

If there are leakages of pottasium or increased cellular uptake what does this lead to

Weakness of muscles - paralysis
Cardiac irregularities - cardiac arrest

31

What is osmolarity

Concentration of osmotically active particles present in solution