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RUSVM Virology Spring17 > Bornaviridae > Flashcards

Flashcards in Bornaviridae Deck (20)
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1
Q

What is the only virus in the bornavirus genus?

A

Borna disease virus

2
Q

Do bornaviruses have envelopes?

A

Yes

3
Q

Bornaviruses have a single molecule of ________ sense, _________ stranded RNA

A

Negative sense

single stranded

4
Q

What are the major proteins of bornaviruses?

A

Matrix protein- M
Glygoprotein**- G (responsible for induction of neutralizing antibodies)
Nucleoproteins- N

5
Q

Small polypeptide X is abundant where?

A

In the cells - but not in the nucleocapsid of bornaviruses

6
Q

Where do bornaviruses replicate in the cell?

A

Nucleus

7
Q

T/F: Host cells are destroyed when newly replicated viruses leave the cells

A

FALSE

The cells are not destroyed – therefore you can have persistent infection

8
Q

How is borna disease virus (BDV) transmitted and to whom?

A

Oral-nasal route

Wide host range - including humans ZOONOTIC

Mostly horses and sheep (Natural infection)

9
Q

T/F: Mortality is high in horses that develop neurological signs with BDV infections

A

TRUE

10
Q

If the disease of BVD is a mild case, what does that mean for the animals recovery?

A

Recovery is rapid, but persistent infection develops –> become carriers

11
Q

What clinical signs may you see in a horse with BDV?

A

Fever, abnormal behavior (chewing motion without food intake - leads to excessive salivation), depression, head tilt, ataxia

Later stages: paralysis, , nystagmus, blindness, **head pressing

12
Q

How long is the typical course of BDV?

A

3-20 days, resulting in death

13
Q

What is the progression of pathogenesis of BDV?

A

virus passes intra-axonally to olfactory bulbs of the brain –> disseminates through CNS

14
Q

T/F: BDV does not elicit protective immune response

A

TRUE

But, may induce immunopathology: immune system induces the neuro pathology

15
Q

What is the significance of perivascular cuffing?

A

T cells, macrophages, and plasma cells will cluster around vasculature in the brain - can see this on histo

16
Q

What inclusion bodies are pathognomonic for BDV?

A

Joest-Degen

eosinophilic intranuclear inclusion bodies in neurons

17
Q

What is the gold standard test for BVD?

A

FAT - using cerebrospinal fluid or serum

Virus isolation, RT-PCR (for confirmation)

18
Q

T/F: there is a vaccine available for BDV?

A

FALSE

ID and quarantine carriers

19
Q

Where does the Avian bornavirus have tropism to?

A

nervous system

20
Q

What clinical signs are seen in a patients with avian bornavirus and who does it infect?

A

Psittacine birds - parrots

Progressive neuro dysfunction - ataxia, paralytic dilatation of the esophagus and proventriculus, GI tract dysfunction, wt loss