Buzz Flashcards Preview

MSK 2 Post Midterm > Buzz > Flashcards

Flashcards in Buzz Deck (46):
1

HLA-B8/DR3

Myasthenia Gravis

2

HLA DR4

Rheumatoid Arthritis, Giant Cell/Temporal Arteritis

3

HLA-B27

seronegative SpA

4

HLA-B13

Psoriasis vulgaris

5

HLA-B1, B8, DR8, DRQ

Dermatitis Herpetiformis

6

HLA-B12

TEN

7

HLA-B51

Behcet

8

anti-SSa/B

Sjogren

9

anti-centromere

CREST

10

anti-histone
homogenous ANA

drug induced lupus
SHIPPE (sulfa, hydralazine, INZ, Phenytoin, Procainamide, Etanercept)

11

anti-Sm

SLE

12

anti-topoisomerase 1
anti-Scl 70
RNA-polymerase 1 and 3

diffuse scleroderma

13

NHLymphoma

sjogren

14

MALT B lymphoma

sjogren

15

Breast cancer

dermatomyositis

16

Adenocarcinoma, barrett's esophagus

CREST

17

pulmonary artery aneurysm

limited scleroderma

18

interstitial lung disease

diffuse scleroderma

19

aortic aneurysm, pulseless

takayasu arteritis

20

pulmonary embolism (2)

behcet's, aPL syndrome

21

rimmed vacuole, anti-cN1a

incusion body myositis

22

HepB

PAN

23

HepC

Lichen planus

24

beta2-GPI, anti cardiolipin, anti-phospholipid

antiphospholipid syndrome (aPL)

25

HA, vision, chewing, T3 HSR, granulomas, elevated ESR
Dz
Tx

Giant Cell/Temporal ARteritis

Tx: steroids BEFORE biopsy

26

Pulseless, HTN, night sweats, aortic regurg, renal artery stenosis, granulomas, copper wiring
Dz
Tx

Takayasu Arteritis

Tx: steroids

27

Young male, T3 HSR, HepB, livedi reticularis, no lungs, intestinal angina, mononeu. multiplex, glomerular ischemia, P-ANCA, fibrinoid necrosis.

Dz

PAN

28

CRASH & and Burn. young child, later in life coronary artery aneurysm

Dz

Kawasaki

CRASH = Conjuctivitis, Rash (desquam), Adenopathy (LAD), Strawberry tongue, Hand-foot edema & Burn (fever)

29

Male smoker, segmental, gangrene, ulcers, autoamputation, Raynauds
Dz

Buerger

30

Child post URI. Palpable purpura. No Thrombocytopenic Purpura. Arthralgia, abdominal pain. IgA

Dz

HSP

31

Lungs + kidney. Type 2 HSR, Type 4 collagen. Nephritic --> crescents. Glomerular caps, pulmonary caps.

Dz
Tx

Anti-GBM

Tx: plasmapheresis

32

PROSE: Pathery, Recurrent genital ulcers, ORAL ULCERS, Skin (erythema nodosum), Eye (uveitis), DVTs.
large joint arthralgia and ulcers in distal ileum or cecum (ddx CD)

Behcet Syndrome

33

C-ANCA. NP, lung, kidney. granulomas. Saddle nose

Wegner's

34

Asthama, allergies, palpable purpura, P-ANCA, eosinophilia,

Churg Strauss

35

Drug induced SLE: SHIPPE

sulfa, hydralazine, INH, phenytoin, procainamide, Etanercept, (methyldopa)

36

Facial swelling (MALToma), dry mouth (oral candida, caries), dry eyes (keratoC sicca), contractures, Ro/SSA, La/SSB

Sjogrens

37

hypersens --> fibroblasts --> collagen, fibrosis.
Puffy skin, fingertip pitting and nodules. Oral/perioral red spots, perioral furrowing, silicosis (potential cause), GAVE, esophageal dysmotility (-->GERD, aspiration).

scleroderma

38

Young or Mid-age female, bilateral proximal muscles weakness w/o sensory sxs.

DX: Biopsy- perimysial and perivascular inflammation, *perifascicular atrophy.

heliotrope rash, shawl rash, gottron papules (extensor knuckles), Malignancy, CD4. Anti-Jo, increased CK, ANA, Mi-2

Dz
Tx

dermatomyositis

Tx: immunosuppressants

39

Mid-age female, bilateral proximal muscles weakness. Subacute proximal muscle weakness. NO skin changes like. Elevated serum CK, Anti-Jo-1
Muscle bx: endomysial inflammation with invasion of non-necrotic muscle fibers without features suggestive of another dx

Dz
Tx

Polymyositis
Tx: immunosuppressants

40

Male >40-50 yo. Finger flexion or quadriceps weakness
Muscle bx: endomysial inflammation, rimmed vacuoles, invasion of non-necrotic muscle fibers, anti-cN1A autoantibodies.

Dz
Tx

Inclusion body myositis

Tx: supportive

41

Palpable purpura

HSP, CS

42

granulomas

giant cell, takayasu, wegner

43

Associated with GCA
Proximal severe, symmetrical morning and
daylong stiffness, soreness and pain in
shoulder, neck and pelvic girdles
Feelings of weakness a result of pain (as
opposed to PM)
***No inflammation on muscle bx**
Muscle enzymes and EMG normal
Elevated ESR and CRP

Polymalgia Rheumatica

44

Gq1b and GT1a ab; ophthalmoplegia, ataxia, arreflexia

miller fisher

45

anti GM1

multifocal motor neuropathy

46

Hu antibody

carcinomatous sensory neuropathy