Buzz

Question 1

HLA-B8/DR3

Answer 1

Myasthenia Gravis

Question 2

HLA DR4

Answer 2

Rheumatoid Arthritis, Giant Cell/Temporal Arteritis

Question 3

HLA-B27

Answer 3

seronegative SpA

Question 4

HLA-B13

Answer 4

Psoriasis vulgaris

Question 5

HLA-B1, B8, DR8, DRQ

Answer 5

Dermatitis Herpetiformis

Question 6

HLA-B12

Answer 6

TEN

Question 7

HLA-B51

Answer 7

Behcet

Question 8

anti-SSa/B

Answer 8

Sjogren

Question 9

anti-centromere

Answer 9

CREST

Question 10

anti-histone

homogenous ANA

Answer 10

drug induced lupus

SHIPPE (sulfa, hydralazine, INZ, Phenytoin, Procainamide, Etanercept)

Question 11

anti-Sm

Answer 11

SLE

Question 12

anti-topoisomerase 1
anti-Scl 70
RNA-polymerase 1 and 3

Answer 12

diffuse scleroderma

Question 13

NHLymphoma

Answer 13

sjogren

Question 14

MALT B lymphoma

Answer 14

sjogren

Question 15

Breast cancer

Answer 15

dermatomyositis

Question 16

Adenocarcinoma, barrett’s esophagus

Answer 16

CREST

Question 17

pulmonary artery aneurysm

Answer 17

limited scleroderma

Question 18

interstitial lung disease

Answer 18

diffuse scleroderma

Question 19

aortic aneurysm, pulseless

Answer 19

takayasu arteritis

Question 20

pulmonary embolism (2)

Answer 20

behcet’s, aPL syndrome

Question 21

rimmed vacuole, anti-cN1a

Answer 21

incusion body myositis

Question 22

HepB

Answer 22

PAN

Question 23

HepC

Answer 23

Lichen planus

Question 24

beta2-GPI, anti cardiolipin, anti-phospholipid

Answer 24

antiphospholipid syndrome (aPL)

Question 25

HA, vision, chewing, T3 HSR, granulomas, elevated ESR Dz Tx

Answer 25

Giant Cell/Temporal ARteritis Tx: steroids BEFORE biopsy

Question 26

Pulseless, HTN, night sweats, aortic regurg, renal artery stenosis, granulomas, copper wiring Dz Tx

Answer 26

Takayasu Arteritis Tx: steroids

Question 27

Young male, T3 HSR, HepB, livedi reticularis, no lungs, intestinal angina, mononeu. multiplex, glomerular ischemia, P-ANCA, fibrinoid necrosis. Dz

Answer 27

PAN

Question 28

CRASH & and Burn. young child, later in life coronary artery aneurysm Dz

Answer 28

Kawasaki CRASH = Conjuctivitis, Rash (desquam), Adenopathy (LAD), Strawberry tongue, Hand-foot edema & Burn (fever)

Question 29

Male smoker, segmental, gangrene, ulcers, autoamputation, Raynauds Dz

Answer 29

Buerger

Question 30

Child post URI. Palpable purpura. No Thrombocytopenic Purpura. Arthralgia, abdominal pain. IgA Dz

Answer 30

HSP

Question 31

Lungs + kidney. Type 2 HSR, Type 4 collagen. Nephritic --> crescents. Glomerular caps, pulmonary caps. Dz Tx

Answer 31

Anti-GBM Tx: plasmapheresis

Question 32

PROSE: Pathery, Recurrent genital ulcers, ORAL ULCERS, Skin (erythema nodosum), Eye (uveitis), DVTs. large joint arthralgia and ulcers in distal ileum or cecum (ddx CD)

Answer 32

Behcet Syndrome

Question 33

C-ANCA. NP, lung, kidney. granulomas. Saddle nose

Answer 33

Wegner's

Question 34

Asthama, allergies, palpable purpura, P-ANCA, eosinophilia,

Answer 34

Churg Strauss

Question 35

Drug induced SLE: SHIPPE

Answer 35

sulfa, hydralazine, INH, phenytoin, procainamide, Etanercept, (methyldopa)

Question 36

Facial swelling (MALToma), dry mouth (oral candida, caries), dry eyes (keratoC sicca), contractures, Ro/SSA, La/SSB

Answer 36

Sjogrens

Question 37

hypersens --> fibroblasts --> collagen, fibrosis. Puffy skin, fingertip pitting and nodules. Oral/perioral red spots, perioral furrowing, silicosis (potential cause), GAVE, esophageal dysmotility (-->GERD, aspiration).

Answer 37

scleroderma

Question 38

Young or Mid-age female, bilateral proximal muscles weakness w/o sensory sxs. DX: Biopsy- perimysial and perivascular inflammation, *perifascicular atrophy. heliotrope rash, shawl rash, gottron papules (extensor knuckles), Malignancy, CD4. Anti-Jo, increased CK, ANA, Mi-2 Dz Tx

Answer 38

dermatomyositis Tx: immunosuppressants

Question 39

Mid-age female, bilateral proximal muscles weakness. Subacute proximal muscle weakness. NO skin changes like. Elevated serum CK, Anti-Jo-1 Muscle bx: endomysial inflammation with invasion of non-necrotic muscle fibers without features suggestive of another dx Dz Tx

Answer 39

Polymyositis | Tx: immunosuppressants

Question 40

Male >40-50 yo. Finger flexion or quadriceps weakness Muscle bx: endomysial inflammation, rimmed vacuoles, invasion of non-necrotic muscle fibers, anti-cN1A autoantibodies. Dz Tx

Answer 40

Inclusion body myositis Tx: supportive

Question 41

Palpable purpura

Answer 41

HSP, CS

Question 42

granulomas

Answer 42

giant cell, takayasu, wegner

Question 43

``` Associated with GCA Proximal severe, symmetrical morning and daylong stiffness, soreness and pain in shoulder, neck and pelvic girdles Feelings of weakness a result of pain (as opposed to PM) ***No inflammation on muscle bx** Muscle enzymes and EMG normal Elevated ESR and CRP ```

Answer 43

Polymalgia Rheumatica

Question 44

Gq1b and GT1a ab; ophthalmoplegia, ataxia, arreflexia

Answer 44

miller fisher

Question 45

anti GM1

Answer 45

multifocal motor neuropathy

Question 46

Hu antibody

Answer 46

carcinomatous sensory neuropathy