Sachen Flashcards

(49 cards)

1
Q

What radiculopathy?

scapular pain,​ “tight band around elbow feeling”, 3rd digit numb, absent triceps jerk

A

C7 nerve root compression (C6-C7) - most common cervical radiculopathy

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2
Q

Hand sensory mnemonic

A
C6 = "six shooter"
C7 = middle finger
C8 = ring/pinky finger
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3
Q

What radiculopathy?
dorsal thigh and lateral calf pain, lateral calf numb, weak hip E and loss of all foot movements EXCEPT can still plantarflex

A

L5 nerve root compression (L4-L5) - most common lumbar radiculopathy

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4
Q

What radiculopathy?

post thigh/post calf pain. Postlat calf and lat food numb. Weakness of hip E and foot plantarflexion.

A

S1 nerve root compression (L5-S1) - most common lumbar radiculopathy

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5
Q

Triceps reflex

A

C7

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6
Q

Biceps reflex

A

C5/C6

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7
Q

Finger flex reflex

A

C8

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8
Q

Patellar reflex

A

L4

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9
Q

Achilles reflex

A

S1

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10
Q

what is mononeuropathy multiplex?

A

multiple mononeuropathies - focal involvement of two or more nerves.

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11
Q

CNS (UMN) v. PNS (LMN)

  • Paresis
  • Tone (flaccid/spastic)
  • Bulk (atrophic or normal)
  • Fasciculations (Y/N)
  • DTRs (hyper/hypo)
  • Plantar reflex
A
  • Paresis: patterns v. distal
  • Tone: spastic v. flaccid
  • Bulk: normal v. atrophic
  • Fasciculations: no v. sometimes
  • DTRs: hypERactive v. hypoactive
  • Plantar reflex: Babinski v. absent
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12
Q

What type of neuropathy is this:

symmetric, LMN sx stocking/glove sensory loss ­ distal numb/weak (foot/hand) instead of calf

A

polyneuropathy

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13
Q

What type of fiber results in this sensory peripheral neuropathy:

  • Negative: ↓vibration, ↓proprioception, ataxia, ↓2pt. discrim.
  • Positive: Tingling, pins and needles
A

large myelinated fiber sensory

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14
Q

What type of fiber results in this sensory peripheral neuropathy:

  • Negative: ↓p/t impairment
  • Positive: burning/jabbing
A

small unmyelinated fiber sensory

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15
Q

Do nerve roots and peripheral nerves:

-split digits (Y/N)

A

● Nerve roots DO NOT split digits: ​Pure C8 root lesion​ → 4th + 5th finger sensory defects
● Peripheral nerves SPLIT digits: Median N lesion (Carpal tunnel​ involving lgmts of palmaris longis + pronator teres) → 1st ­- 3rd finger + lateral 1⁄2 of ring finger defects

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16
Q

Froment sign = what nerve and what mm?

A

adductor pollicus weakness; ulnar nerve palsy

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17
Q

Saturday night palsy -midshaft humerus fracture, axilla compression.

What nerve? What clinical signs?

A

WRIST DROP due to paresis of extensor muscles of wrist, finger, thumb.

Radial nerve compression in the spiral groove

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18
Q

Fibular head/neck compression from sitting cross legged - what nerve and what clinical features?

A

PERONEAL N ENTRAPMENT - Motor weakness of dorsiflexion, eversion, toe extension. Sensory loss dorsum of foot.

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19
Q

What nerve causes: lateral thigh pain, foot drop, absent ankle jerk

A

sciatic compression (i.e. injection in buttocks in wrong location)

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20
Q

What Hereditary Polyneuropathy and what type of dysfunction/etiology?
● weakness in walking/running is 1st symptom (1st­-2nd​ decade). ​“Doc, I can’t keep up during sports”
● INVERTED CHAMPAGNE BOTTLE LEGS (severe distal SYMMETRIC ATROPHY; LEGS​>arms), HAMMER TOES (chronic), pes cavus, skeletal deformities

A

Charcot­-Marie-­Tooth 1 Neuropathies (hereditary motor sensory neuropathies)

DEMYELINATING

21
Q

What Hereditary Polyneuropathy and what type of dysfunction/etiology?
● onset: adulthood; AD
● Distal symmetric atrophy (legs>arms)

A

Charcot­-Marie-­Tooth 1 Neuropathies (hereditary motor sensory neuropathies)

neuronal/axon LOSS

22
Q

Difference between HMSN1 and HMSN2 EMG

A
  • HMSN 1 EMG: slow motor N. conduction (demyelination)

- HMSN 2 EMG: EMG: almost nml motor N. conduction velocities (axonal loss)

23
Q

Low back/leg pain is first sign, then ascending symmetric motor paralysis (no­minimal sensory)​; self resolving (after 6w).

A

Acute Inflammatory Demyelinating Polyneuropathy (GBS)

24
Q

Etiology/triggering event in Acute Inflammatory Demyelinating Polyneuropathy

A

prior infection with Campylobacter JEJUNI, Mycoplasma pneumonia, EBV

25
Indicative of what Dz? - ***​↑protein, nml cell count, nml glucose ***= albumin-­cytological dissociation - NCVS​: slow conduction, prolonged F waves
Acute Inflammatory Demyelinating Polyneuropathy
26
Tx of GBS
plasma exchange or IVIg, NEVER USE STEROIDS
27
Sudden ANS changes to look for in Acute Inflammatory Demyelinating Polyneuropathy
arrhythmias (brady/tachy), HTN/hypoT, Resp failure
28
How is the Variant of GBS, Miller-­Fisher Syndrome, different than normal GBS?
- Children - ***Ophthalmoplegia, ataxia, arreflexia*** - dysphagia, dysarthria - ***GQ1b and GT1a ab’s***
29
Difference between Acute Inflammatory Demyelinating polyneuropathy and Chronic Inflammatory Demyelinating Polyneuropathy
CIDP lasts longer than AIDP and is REPLAPSING.
30
Treatment for Chronic Inflammatory Demyelinating polyneuropathy
Tx: IVIg, steroids, plasma exchange, immunosuppression [Cyclophosphamide (Cytoxan); Azathioprine (Imuran)]
31
M>F. Single n. to start → progressive distal weakness (upper extremity/HANDS>feet) GM-1ab ● No sensory sx, no UMN findings
Multifocal Motor Neuropathy
32
Serum GM-1 ab titer in Multifocal Motor Neuropathy: what makes a worse prognosis. Tx of Multifocal Motor Neuropathy
Increased titer means worse prognosis. Tx: IVIg
33
Eyes "down and out" with complete ptosis and DILATED-UNREACTIVE v. REACTIVE pupil. What cranial nerve is compressed and what etiologies?
Dilated/unreactive: PCA aneurysm - compressive CN3 neuropathy Reactive: DM neuropathy - inflammatory neuropathy (#1 MCC)
34
- Initial complaints: gait disorder, limb weakness, speech or swallowing. - Unexplained wt loss, DIFFICULTY SWALLOWING/tongue atrophy and mm cramps/fasciculations
Amyotrophic Lateral Sclerosis
35
○ Degeneration of any or combo of the following leads to ___? Pyramidal Betz cells, **ANTERIOR HORN CELLS and LATERAL/VENTRAL CORTICOSPINAL TRACTS** and Corticobulbar Tract, brainstem lower CN motor nuclei
ALS *Hallmark: UMN and LMN denervation in one limb
36
EMG in ALS shows:
widespread innervation and denervation
37
What are the important "rule of thumb" Diagnostic Negatives in ALS?
■ No sensory or extraocular loss ■ Nml mentation ■ No bowel or bladder issues ■ Decubiti (pressure ulcer) rare
38
Death in ALS due to...
rspiratory failure.
39
While tx for ALS is supportive, what glutamate inhibitor prolongs life by a few months?
Riluzol
40
What is this: ○ 20% of MND, ***brainstem lower CN motor nuclei*** ○ Dysarthria, dysphagia, chewing issues, respiratory difficulty, dysphonia (nasal tone) ○ Progresses to ALS
Progressive Bulbar Palsy
41
What is this? ○ 10% of MND, M more than F, ***mean onset 64, AH cells, LMN deficits,*** rarely progresses to ALS (better prognosis than ALS)
Progressive Spinal Muscular Atrophy
42
What is this? ○ 2­4% of MND, 50­55yo, UMN, CST deficit ○ Weakness, spasticity, hyperreflexia,+ Babinski ○ Slow progression but can evolve to ALS ○ Better prognosis than ALS
Primary Lateral Sclerosis
43
What childhood motor neuron disease is this? | ­​Hypotonia, areflexia, poor suck, breathing issues, death in 6-­12mo
Infantile SMA (Werdnig-Hoffmann Dz) Kugelberg-Welander Dz is milder than WH
44
Two presynaptic disorders of NMJ.
LEMS (VGCaC), Botulism (blocks presynaptic ACh release)
45
One postsynaptic disorder of NMJ.
Myasthenia Gravis (postsynaptic nAChRs)
46
What NMJ disorder has ocular weakness with ptosis, diplopia/double vision and NORMAL reflexes?
Myasthenia gravis tx with ACHEi (mestinon), predinosne (aminoglycosides have sig drug interaction with MG)
47
What NMJ disorder has association with Small Cell Lung Cancer. Strength improves with exercise. ARREFLEXIA.
LEMS tx Guanidine hydrochloride
48
Don't give LEMS pts with heartburn what?
Mg2+. because inc Mg = dec Ca influx = LEMS exacerbation
49
What NMJ disorder has Descending: dry mouth, blurred vision, resp/limb paralysis
Botulism