Vesiculobullous Diseases Flashcards Preview

MSK 2 Post Midterm > Vesiculobullous Diseases > Flashcards

Flashcards in Vesiculobullous Diseases Deck (22):
1

Highly contagious superficial skin infection. Rapid blister, asx, FLACCID

Impetigo.

"Honey crusted lesion"

Bullous impetigo.

2

Most common causes of impetigo

Staph aureus or Strep pyogenes. Infect skin breaks (i.e. due to atopic dermatitis, herpes infection, trauma).

3

Tx of impetigo

antibiotics

4

Toxin mediated exfoliative dermatitis. Exotoxin destroys keratinocyte attachments in straum granulosum only, Fever, orange/red macules, sloughing of upper layers of epidermis. Children/infants/daycares/renal failure.

What is this?
Physical exam sign

Staph Scalded Skin Syndrome

+ Nikolsky sign (rubbed area of skin sloughs off)

5

Pathogenesis of SSSS

Staph aureus, type 2

6

Skin and oral mucosa with flaccid intraepidermal bulla. IgG autoantibody against Desmoglein 3

Pemphigus Vulgaris

7

Physical exam signs of Pemphigus Vulgaris

+ Nikolsky (rubbed area of skin sloughs off)
+ Asboe-Hansen Sign (lateral prssure on bulla will spread bulla to uninvolved skin)

8

What disease is associated with PV?
Dx and tx of Pemphigus Vulgaris?

Myasthenia gravis and thymoma are associated with PV.
Dx - biopsy
Tx - imuran, prednisone, Consult opthomology

9

Encephalitis, seizures, HA. Spread by respiratory droplets or genetalia contact. Prodrome: itching/burning. Vescicles/ulcer on erythematous base, recurrent.

What is this?

HSV1 (oral)
HSV2 (Gentalia)

10

What is herpetic whitlow and herpes gladitorum

Whitlow - herpes n finger
gladitorium - along ears, in wrestlers

11

"Dew drop on rose petal" or "oval teardrop on erythematous base".
Face/trunk, aphthous ulcers, spares distal extremities.

Varicella Zoster virus (chickenpox).

12

Do not give what to to peds with VZ Virus
Tx

Aspirin
Tx - VZIG, antivirals, antihistamines

13

Autoantibodies of IgG against __ antigens 1 and 2. Chronic, autoimmune, SUBepidermal blistering.

Tense bulla containing eospinohils.

Bullpous pemphigoid.

14

Immunofluorescence of BP.
tx of bullous pemphigoid

Linear pattern
prednisone, immunosuppressives

15

Type 4 HSR. Idiopathic photodermatoses relating to sun exposure (UV-A or UV-B). Native American! Spring time! 30 min after sun exposure.

Polymorphous Light Eruption

16

Rare immune mediated skin disease with gluten sensitive enteropathy. IgA mediated (dermal papilla).

Dermatitis Herpetiformis

17

A person presents with pruritic, grouped/symmetric/burning skin blisters. Urticarial wheal to vescicle to bulla.

What is this?

What immunologic markers?

Dermatitis Herpetiformis
Increased expression of HLA-B1, B8, DR8, DRQ

18

Tx of dermatitis herpetiformis.

dapson, gluten free diet

19

B9, self limiting eruption. Targetoid or iris shaped macules or vesiculopapules on palms or soles. Dull red, sometimes mucosal involvent, symmetric involvement.

What is this?
What associated phenomenon? Associated infection?

Erythema multiforme

Koebner phenomenon

HSV

20

The major variant of Erythema Multiforme must be hospitalized bc...

affects oropharynx

21

Extensive full thickness skin attachment. 1-3 week prodrome with fever, skin tenderness/pain, crinkled surface. Associated with HLA-B12, worse in SLE, HLA, meds/infections.

What is this?
What sign is associated with it?

Toxic Epidermal Necrolysis

+Nikolsky

22

Tx of TEN

IV fluids, burn unit, steroids as last resort.