Papulosquamous Diseases 1 and 2 Flashcards Preview

MSK 2 Post Midterm > Papulosquamous Diseases 1 and 2 > Flashcards

Flashcards in Papulosquamous Diseases 1 and 2 Deck (28):
1

Define papulosquamous

Morphologic dermatologic condition consisting of mainly papules and scale (squamous)

2

SCALY WHITE PLAQUES OVER ELBOWS AND KNEEES. A chronic inflammatory scaling eruption. HLA-B13, AD.

Psoriasis vulgaris

3

Branny, greasy red scales on face/chest/penis. Mild flaking in hair baring areas ("dandruff skin").

Seborrheic dermatitis

4

Pathogenesis of sborrheic dermatitis.

Abnormal immune response to P. OVALE (with normal amt of yeast), resulting in free fatty acid release.

5

Chronic infection, **DM patients**, red/brown scaly macules with an erosive collarette-like scale in warm/moist areas (toes, groin, axilla).

Erythrasma

6

Describe visualization test of erythasma.

Describe pathogenesis (G+ rod, normal skin flora)

Wood's Lamp

Corynebacterium minutissimum.

7

Wickham's stria. Painful/burning at wrists/nails/oral cavity/genatalia. Sawtooth Band like infiltrate at DEJ. M=F, 30-60 years.

What is this?

What is the pathognomonic description?

What virus is associated with this?

Lichen Planus

Pruritic, Polygonal, Purple, Plaque ( greater than 1cm), Papule (less than 1cm)

Hep C

8

Rose pink colored scaly erythematous patches or thin palques. CD4+ and Langerhan's cells in dermis.

What is this? What sex does it affect? What time of year?

Pityriasis rosea

Spring or fall, F>M 2:1

9

Describe the pattern of spread of of pityriasis rosea.

Starts at Herald Patch on person's back. Spreads on "Christmas tree"distribution on trunk.

10

Superficial infection of the skin that results in tinea corporis.

Lab test.

Dermatophyte infection with trichophyton, microsporum, epidermophyton, T. rubrum.

KOH

11

Pathophysiology of dermatophyte infection.

Nonliving cornified skin/hair/nail. Tx the source, NOT with antifungals.

12

Reddish-orange scaling plaques of unknown etiology with palmoplantar keratoderma and follicular keratotic papules.

What is this?

Due to what deficincy?

Pityriasis rubra pilaris

13

Pathogenesis of pityriasis rubra pilaris

vitamin A deficiency. AD inheritance

14

What type of pityriasis rubra pilaris has red brown plaques with islands of sparing?

Similar type that is associated with virus?

type 1 - classic adult, most common

Type 6 - HIV

15

What type of pityriasis rubra pilaris has glove and stocking distribution?

type 2

16

What type of pityriasis rubra pilaris affects CHILDREN

type 3 - classic juvenile

17

What type of pityriasis rubra pilaris is well demarcated follicular hyperkeratosis along elbows and knees

type 4 - circumscribed Juvenile

18

What type of pityriasis rubra pilaris has follicular hyperkeratosis with scleroderma like palms and soles?

type 5 - Atypical juvenile

19

treatment of pityriasis rubra pilaris

biopsy, then administer retinoids

20

Pruritic, scaling plaques that mimic eczema. Red-brown shades or hypopigmented. Round, oval, annular or bizarre shaped cells. M>F, >50years old, LN and Organs involved.

Cutaneous T Cell Lymphoma

21

Dx CTCL

biopsy, CXR, CBC with Buffy coat for SEZARY CELLS.

22

Tx of CTCL

topical steroids, PUVA, topical nitrogen mustard.

23

Scarring atrophic photosensitizing dermatosis. Results in pruritic, erythematous papule or plaque with modesl scaling. Hypo or hyper pigmented. Mucosa, palms, soles. 20-40yo/M=F.

Discoid Lupus Erythematosus

24

Pathogenesis of Discoid Lupus Erythematosis

Chronic DLE is at risk for developing...

UV induced HSP

At risk for developing SCCa

25

Tx of Discoid Lupus Erythematosis

sunscreen, topical steroids, Intralesional steroids, surgery, antimalarials

26

Papulosquamous, pustular, bullous, EM-like, TEN, fixed.

How long from inciting factor (and what is the inciting factor)?

Drug eruption 2-3 weeks post starting drug.

27

What do these cause?
Coumadin
Silver nitrate
Doxycycline

What is Jarisch-Herxheimer Reaction?

Coumadin - purpura
Silver nitrate - argyria (skin turns blue-grey)
Doxycycline - phototoxic

Jarisch-Herxheimer Reaction - Bug toxins released after antibiotic kills bugs

28

What types of HSR:
-urticaria
-cytotoxic
-cell mediated immune complex
-delayed HS

Type 1-4