Flashcards in Buzzwords For Heme/Lymph Final Deck (68)
A patient presents with fatigue, decreased propioception on their legs, and spastic paresis. What substrate has built up and where?
Methylmalonic acid has build up in the dorsal and lateral tracts of the spinal cord causing demyelination.
A Person with pancreatic insufficiency is subjected to what type of anemia
Vitamin B12 deficient anemia.
Pancreatic enzymes cleave R-binder, which release Vit. B12 from R-binder and allows it to bind to IF in the small intestine.
Why should folate not be used to treat Vitamin B12 deficiency?
Folate will cure the anemia, but will NOT treat the neurologic symptoms
What is the essential test for diagnosis of Autoimmune hemolytic anemia?
Direct Coombs Test
What disease is most commonly associated with Warm Autoimmune Hemolytic Anemia?
What drugs are most commonly associated with Warm Autoimmune Hemolytic Anemia?
Methyldopa & Penicillin/Cephalosporin
Penicillin causes a response while bound to the RBC while methyldopa causes generation of AB against RBCs
A patient presents with acrocyanosis, Raynaud's phenomenon, and anemia, what isotype of AB is elevated in their blood?
Agglutination exasperated with cold exposure. Hemolysis due to COMPLEMENT!