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Flashcards in Buzzwords For Heme/Lymph Final Deck (68)
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61

A patient presents with fatigue, decreased propioception on their legs, and spastic paresis. What substrate has built up and where?

Methylmalonic acid has build up in the dorsal and lateral tracts of the spinal cord causing demyelination.

62

A Person with pancreatic insufficiency is subjected to what type of anemia

Vitamin B12 deficient anemia.
Pancreatic enzymes cleave R-binder, which release Vit. B12 from R-binder and allows it to bind to IF in the small intestine.

63

Why should folate not be used to treat Vitamin B12 deficiency?

Folate will cure the anemia, but will NOT treat the neurologic symptoms

64

What is the essential test for diagnosis of Autoimmune hemolytic anemia?

Direct Coombs Test

65

What disease is most commonly associated with Warm Autoimmune Hemolytic Anemia?

SLE

66

What drugs are most commonly associated with Warm Autoimmune Hemolytic Anemia?

Methyldopa & Penicillin/Cephalosporin

Penicillin causes a response while bound to the RBC while methyldopa causes generation of AB against RBCs

67

A patient presents with acrocyanosis, Raynaud's phenomenon, and anemia, what isotype of AB is elevated in their blood?

IgM

Agglutination exasperated with cold exposure. Hemolysis due to COMPLEMENT!

68

In G6PDH Deficiency, protection from oxidative stress is lacking because no _____ is produced so __________ is not made

In G6PDH Deficiency, protection from oxidative stress is lacking because no NADPH is produced so Glutathione is not made