Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Cancer associations > Flashcards

Cancer associations Flashcards

1
Q

BCR-ABL

A

tyrosine kinase

CML, ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

bcl-2

A

anti-apoptotic molecule (inhibits apoptosis)

follicular and undifferentiated lymphomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

BRAF

A

serine/threonine kinase

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

c-kit

A

cytokine receptor (stem cell factor)

gastrointestinal stromal tumor (GIST)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

c-myc

A

transcription factor

Burkitt lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

HER2/neu

c-erbB2

A

tyrosine kinase

breast, ovarian, and gastric carcinomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

L-myc

A

transcription factor

Lung tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

N-myc

A

transcription factor

Neuroblastoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ras

A

GTPase

colon cancer, lung cancer, pancreatic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ret

A

Tyrosine kinase

MEN 2A and 2B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

APC

A

Colorectal cancer (associated with FAP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

BRCA1

A

DNA repair protein

breast and ovarian cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

BRCA2

A

DNA repair protein

breast and ovarian cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CPD4/SMAD4

A

DPC (Deleted in Pancreatic Cancer)

Pancreatic cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

DCC

A

DCC (Deleted in Colon Cancer)

Colon cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MEN1

A

MEN type 1:

  • Pituitary
  • Pancreas
  • Parathyroid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

NF1

A

RAS GTPase activating protein (neurofibromin)

Neurofibromatosis 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

NF2

A

Merlin (schwannomin) protein

Neurofibromatosis 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

p16

A

cyclin-dependent kinase inhibitor 2A

melanoma

20
Q

p53

A

transcription factor for p21, blocks G1 to S phase

most human cancers
Li-Fraumeni syndrome

21
Q

PTEN

A

breast, prostate, endometrial cancer

22
Q

Rb

A

Inhibits E2F; blocks G1 to S phase

Retinoblastoma, osteosarcoma

23
Q

TSC1

A

hamartin protein

tuberous sclerosis

24
Q

TSC2

A

tuberin protein

tuberous sclerosis

25
Q

VHL

A

Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease

26
Q

WT1

A

Wilms Tumor

nephroblastoma

27
Q

WT2

A

Wilms Tumor

nephroblastoma

28
Q

Alk phos

A

bone metastasis
Paget disease
Seminoma

29
Q

alpha-fetoprotein

A 
HCC
hepatoblastoma
yolk sac tumors
testicular cancer
mixed germ cell tumor (with HCG)
30
Q

beta-hCG

A

Hydatidiform moles
Choriocarcinomas
Testicular cancer

31
Q

CA-15-3

CA-27-29

A

breast cancer

32
Q

CA-19-9

A

pancreatic adenocarcinoma

33
Q

CA-125

A

ovarian cancer

34
Q

calcitonin

A

medullary thyroid carcinoma

35
Q

CEA

A

CarcinoEmbryonic Antigen:
70% of colorectal and pancreatic cancers
also: breast, gastric, and medullary thyroid carcinomas

36
Q

S-100

A

neural crest origin:

  • melanoma
  • neural tumors
  • schwannomas
  • Langerhans cell histiocytosis
37
Q

TRAP

A

TRAP: Tartate-Resistant Acid Phosphatase

Hairy cell (B-cell) leukemia

38
Q

EBV

A

Burkitt Lymphoma
Hodgkin Lymphoma
nasopharyngeal cancer
CNS lymphoma (immunocompromised pts)

39
Q

Hep B/Hep C

A

HCC

40
Q

HHV-8

A

Kaposi sarcoma

body cavity fluid B-cell lymphoma

41
Q

HPV

A

HPV 16, 18: cervical and penile/anal carcinoma, head/neck/throat cancer

42
Q

H.pylori

A

Gastric adenocarcinoma

MALT lymphoma

43
Q

HTLV-1

A

Adult T-cell leukemia/lymphoma

44
Q

Liver fluke

Clonorchis sinensis

A

Cholangiocarcinoma

45
Q

Schistosoma haematobium

A

Bladder cancer (squamous cell)

Pharmacology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions