From Jen: G protein second messenger

Question 1

alpha 1

Answer 1

Gq sympathetic

↑ vascular smooth muscle contraction

↑ pupillary dilator muscle contraction (mydriasis)

Question 2

alpha 2

Answer 2

Gi sympathetic

↓ sympathetic outflow
↓ insulin release

Question 3

beta 1

Answer 3

Gs sympathetic

↑ HR, contractility
↑ renin release
↑ lipolysis

Question 4

beta 2

Answer 4

Gq sympathetic

Vasodilation, bronchodilation
↑ HR, contractility
↑ lipolysis
↑ glucagon release
↓ uterine tone

Question 5

M1

Answer 5

Gq parasympathetic

CNS, enteric nervous system

Question 6

M2

Answer 6

Gi parasympathetic

↓ HR and contractility

Question 7

M3

Answer 7

Gq parasympathetic

Increase exocrine secretions, gut peristalsis
bronchoconstriction
pupillary muscle constriction (miosis)
ciliary muscle constriction (accommodation)

Question 8

D1

Answer 8

Gs dopaminergic

Relax renal vascular smooth muscle

Question 9

D2

Answer 9

Gi dopaminergic

Modulate transmitter release, especially in brain

Question 10

H1

Answer 10

Gq histamine

increase nasal and bronchial mucous production
contract bronchioles
itch, pain

Question 11

H2

Answer 11

Gs histamine

increase gastric acid secretion

Question 12

V1

Answer 12

Gq vasopressin

↑ vascular smooth muscle contraction

Question 13

V2

Answer 13

Gs vasopressin

↑ H2O permeability and reabsorption of collecting tubules of kidney