From Jen: Drug reactions by system

Question 1

CV: atropine-like side effects

Answer 1

Tricyclics

Question 2

CV: coronary vasospasm

Answer 2

Cocaine

Sumatriptan

Question 3

CV: cutaneous flushing

Answer 3

Niacin
Calcium channel blockers
Adenosine
Vancomycin

Question 4

CV: dilated cardiomyopathy

Answer 4

Doxorubicin

Daunorubicin

Question 5

CV: Torsades de pointes

Answer 5

Class III (sotalol)
Class IA (quinidine)
Cisapride

Question 6

Heme: Agranulocytosis

Answer 6

Clozapine
Carbamazepine
Colchicine
Propylthiouracil (PTU)
Methimazole

Question 7

Heme: aplastic anemia

Answer 7

Chloramphenicol
Benzene
NSAIDs
Propylthiouracil (PTU)
Methimazole

Question 8

Heme: Direct Coombs-positive hemolytic anemia

Answer 8

Methyldopa

Question 9

Heme: Gray baby syndrome

Answer 9

Chloramphenicol

Question 10

Heme: hemolysis in G6PD deficiency

Answer 10

Isoniazid
Sulfonamides
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

(IS PAIN)

Question 11

Heme: megaloblastic anemia

Answer 11

Phenytoin
Methotrexate
Sulfa drugs

(have a BLAST with PMS)

Question 12

Heme: Thrombotic complications

Answer 12

OCPs

Question 13

Resp: cough

Answer 13

ACE inhibitors (ARB=no cough)

Question 14

Resp: pulmonary fibrosis

Answer 14

Bleomycin
Busulfan
Amiodarone

Question 15

GI: Acute cholestatic hepatitis

Answer 15

Macrolides

Question 16

GI: focal to massive hepatic necrosis

Answer 16

Halothane
Valproic acid
acetaminophen
Amanita phalloides

Question 17

GI: hepatitis

Answer 17

Isoniazid (INH)

Question 18

GI: pseudomembranous colitis

Answer 18

Clindamycin

ampicillin

Question 19

Repro/Endo: adrenal insufficiency

Answer 19

Glucocorticoid withdrawal

Hypothalamic-Pituitary-Adrenal suppression

Question 20

Repro/Endo: gynecomastia

Answer 20

Spironolactone
Digitalis
Cimetidine
Alcohol
Estrogen
Ketaconazole

(Some Drugs Cause Awesome Knockers)

Question 21

Repro/Endo: hot flashes

Answer 21

Tamoxifen

Clomiphene

Question 22

MSK: Gingival hyperplasia

Answer 22

Phenytoin

Question 23

MSK: Gout

Answer 23

Furosemide

Thiazides

Question 24

MSK: osteoporosis

Answer 24

Corticosteroids

Heparin

Question 25

MSK: Photosensitivity

Answer 25

Sulfonamides Amiodarone Tetracycline (SAT for a photo)

Question 26

MSK: Rash, Steven-Johnson syndrome

Answer 26

``` Ethosuximide Lamotrigine Carbamazepine Phenobarbital Phenytoin Sulfa drugs PCN Allopurinol ```

Question 27

MSK: SLE-type syndrome

Answer 27

Hydralazine INH Procainamide Phenytoin (HIPP)

Question 28

MSK: Tendonitis, tendon rupture, cartilage damage (kids)

Answer 28

Fluoroquinolones

Question 29

Renal: | Fanconi's syndrome

Answer 29

Expired tetracycline

Question 30

Renal: | Interstitial nephritis

Answer 30

Methicillin NSAIDs Furosemide

Question 31

Renal: | Hemorrhagic cystitis

Answer 31

Cyclophosphamide | Ifosfamide (prevent by co-administering mesna)

Question 32

Neuro: | Cinchonism

Answer 32

Quinidine | Quinine

Question 33

Neuro: | Parkinson-like syndrome

Answer 33

Haloperidol Chlorpromazine Reserpine Metoclopramide

Question 34

Neuro: | Diabetes insipidus

Answer 34

Lithium | Demeclocycline

Question 35

Neuro: | Seizures

Answer 35

Bupropion Imipenem/cilastatin Isoniazid

Question 36

Neuro: Tardive dyskinesia

Answer 36

Antipsychotics (esp. typicals)

Question 37

Disulfram-like reaction

Answer 37

Metronidazole Certain cephalosporins Procarbazine 1st gen sulfanylureas

Question 38

Nephro/Neurotoxicity

Answer 38

Polymyxins

Question 39

Nephro/Ototoxicity

Answer 39

Aminoglycosides Vancomycin Loop diuretics Cisplatin