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Flashcards in cancer cells Deck (8)
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1

characteristics of cancer cells

Anchorage Independent (grow when anchored or liquid)

Insensitive to pop density

replenished telomeric shortening

block apoptosis/ pass checkpoints

2

How cancers spread

cancers leave tissue of origin, move thru blood stream, invade another tissue and grow (metastasis)

3

What causes cancers

Environment- carcinogens, UV radiation, viruses

Hereditary factors- 10-20% of all cancers

4

What are Proto-oncogenes/ oncogenes

proto- encode pro. that stim cell division, inhibit cell differentiation, halt death

5

What are tumour suppressor genes

in normal cells encode pro. that inhibit cell division

6

How are proto oncogenes converted to oncogenes

point mutation, gene amplification, chromosomal translocation, local DNA rearrangements, Insertional mutagenesis

7

P53 + RB tumor suppressor genes

P53- regulates cell cycle and function, most frequently mutated (1/2 all cancers)

RB- if the gene mutated early in life ], the pro. is inactivated and results in development of retinoblastoma cancer

8

Stepwise accumulation of mutations in oncogenes

1. APC mutation- Early benign tumor

2. KRAS mutation- intermediate benign tumor

3. SMAD4 mutation- late benign tumor

4. P53- localized cancer