Cell cycle

Question 1

Typical length of eukaryotic cell cycle

Answer 1

24h

Question 2

control of the cell cycle must: (3)

Answer 2

1. ensure everything is carried out in right order
2. each phase is completed before next begins
3. respond to external conditions

Question 3

T/F- mature nerve or muscle tissue do not divide

Answer 3

T

Question 4

In which stage is their the most variation in terms of time

Answer 4

G1

Question 5

How is rapid rates of cell division achieved

Answer 5

-by increasing number of replicons

Question 6

By increasing the number of replicons and activating all simultaneously

Answer 6

• S phase completed in less than 3 min

- 100x faster

Question 7

3 key transition points in cell cycle

Answer 7

Late G1
G2-M transision
Metaphase-Anaphase transision

Question 8

Late G1 transition influenced by

Answer 8

Growth factors , nutrients, cell size, dna damage

Question 9

G2-M transison influenced by

Answer 9

cell size, dna damage, dna replication

Question 10

Metaphase-anaphase transition influenced by

Answer 10

chromosome attachments to spindle

Question 11

what is progression thru the cell cycle driven by

Answer 11

Protein Kinases(Cdks), only when bound to cyclin

Question 12

3 types of Cdks

Answer 12

mitotic cyclins- G2-M transition

G1 cyclins- passage thru G1 restriction point

S cyclins- associated w/ DNA replication

Question 13

Active mitotic CDK-cyclin stims 4 thing

Answer 13

1. Nuclear envelope breakdown
2. chromosome condensation
3. Mitotic spindle formation
4. Targeted pro. degradation

Question 14

Mitotic spindle checkpoint

Answer 14

prevents anaphase from starting until all chromosomes are attached to the spindle

Question 15

what activates Anaphase-promoting complex

Answer 15

CDK-cyclin phosphorylates and activates this