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Flashcards in Cell cycle Deck (15)
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1

Typical length of eukaryotic cell cycle

24h

2

control of the cell cycle must: (3)

1. ensure everything is carried out in right order

2. each phase is completed before next begins

3. respond to external conditions

3

T/F- mature nerve or muscle tissue do not divide

T

4

In which stage is their the most variation in terms of time

G1

5

How is rapid rates of cell division achieved

-by increasing number of replicons

6

By increasing the number of replicons and activating all simultaneously

-S phase completed in less than 3 min
-100x faster

7

3 key transition points in cell cycle

Late G1
G2-M transision
Metaphase-Anaphase transision

8

Late G1 transition influenced by

Growth factors , nutrients, cell size, dna damage

9

G2-M transison influenced by

cell size, dna damage, dna replication

10

Metaphase-anaphase transition influenced by

chromosome attachments to spindle

11

what is progression thru the cell cycle driven by

Protein Kinases(Cdks), only when bound to cyclin

12

3 types of Cdks

mitotic cyclins- G2-M transition

G1 cyclins- passage thru G1 restriction point

S cyclins- associated w/ DNA replication

13

Active mitotic CDK-cyclin stims 4 thing

1. Nuclear envelope breakdown
2. chromosome condensation
3. Mitotic spindle formation
4. Targeted pro. degradation

14

Mitotic spindle checkpoint

prevents anaphase from starting until all chromosomes are attached to the spindle

15

what activates Anaphase-promoting complex

CDK-cyclin phosphorylates and activates this