Flashcards in Messengers + receptors Deck (10)
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1
where do hydrophilic and hydrophobic ligands bind
hydrophilic- extracellular receptors
hydrophobic- intracellular receptors
2
What do G protein linked receipts contain
7 transmembrane a helices
extracellular loops to bing specific messengers
Intracellular loops that interact w specific g proteins
3
When are G proteins “on”, “off"
GTP bound= on
GDP bound= off
4
Two classes of G proteins
large hetêrotrimeriç (Gaby)
small monomeric
5
What is cAMP, how is it formed what is the target protein
-second messenger for some g proteins
-formed from ATP
-Target is protein kinase A (regulates PKA)
6
what increases cytosolic Ca+
Opening of calcium channels in PM
calcium release from ER
7
what decreases cytosolic Ca+
calcium ATPases (transport ca out)
mitochondria take up Ca
8
Two categories of protein kinase associated receptors
1. tyrosine kinases, that phosphorylate a try residue
2. serine/threonine kinases, that phosphorylate a Sea or The residue
9
Steps of RTK single transduction cascade
ligand binding
dimerization of RTKs
autophosphorylation
phosphorylated RTK recruits pro. with SH2 domain
10