Messengers + receptors Flashcards by Marco DiFederico | Brainscape

Flashcards in Messengers + receptors Deck (10)

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1

where do hydrophilic and hydrophobic ligands bind

hydrophilic- extracellular receptors

hydrophobic- intracellular receptors

2

What do G protein linked receipts contain

7 transmembrane a helices
extracellular loops to bing specific messengers
Intracellular loops that interact w specific g proteins

3

When are G proteins “on”, “off"

GTP bound= on
GDP bound= off

4

Two classes of G proteins

large hetêrotrimeriç (Gaby)
small monomeric

5

What is cAMP, how is it formed what is the target protein

-second messenger for some g proteins
-formed from ATP
-Target is protein kinase A (regulates PKA)

6

what increases cytosolic Ca+

Opening of calcium channels in PM
calcium release from ER

7

what decreases cytosolic Ca+

calcium ATPases (transport ca out)
mitochondria take up Ca

8

Two categories of protein kinase associated receptors

1. tyrosine kinases, that phosphorylate a try residue

2. serine/threonine kinases, that phosphorylate a Sea or The residue

9

Steps of RTK single transduction cascade

ligand binding
dimerization of RTKs
autophosphorylation
phosphorylated RTK recruits pro. with SH2 domain

10

4 categories of endocrine hormones

amino acid derivates (epinephrine)
peptides (vasopressin)
Proteins (insulin)
Lipid like hormones (test)