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Step pharm > Cancer drug Associations > Flashcards

Cancer drug Associations Flashcards

1
Q

Erlotinib

A

EGFR tyrosine kinase inhibitor (earl)

Non small cell lung carcinoma

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2
Q

Nitrosureas

A

Alkylating agent, brain tumors

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3
Q

Etoposide

A

Inhibit topoisomerase II (side of tower)

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4
Q

Paclitaxel, other taxanes

A

Hyperstabilize polymerized microtubules in M phase (tarzan)

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5
Q

Busulfan

A

Alkylating agent, treatment before BMT (beautiful sirens)

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6
Q

Bleomycin

A

Induce free radical formation DNA strands (whale)

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7
Q

Topotecan

A

Inhibit topoisomerase I (tucan)

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8
Q

Azathioprine, 6-mercaptopurine

A

Purine analog –> Blocks IMP synthesis

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9
Q

Bevacizumab

A

Monoclonal Ab against VEGF (beverage lady)

Wet age related macular degeneration

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10
Q

Vincristine

A

Binds beta tubulin, inhibit its polymerization (Tarzans girl)

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11
Q

Hydroxyurea

A

Ribonucleotide reductase inhibitor (lady hitting hostess)

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12
Q

Daunorubicin

A

Generates free radicals, Intercalate in DNA (ruby)

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13
Q

Vemurafenib

A

BRAF inhibitor V600E-mutation (Ben Franklin Venom)

metastatic melanoma

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14
Q

Methotrexate

A

Folic acid analog –> inhibits dihydrofolate reductase

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15
Q

Cisplatin

A

Cross link DNA

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16
Q

Ifosfamide

A

Alkylating agent

17
Q

Rituximab

A

Monoclonal Ab against CD20 (coronation ritual)

18
Q

Traztuzumab

A

Herceptin

Monoclonal Ab against HER-2

19
Q

Raloxifene

A

SERM

20
Q

Imatinib

A

Tyrosine kinase inhibitor of BCR-ABL (imitate)

CML, GIST

21
Q

Doxorubicin

A

Generates free radicals, Intercalate in DNA (ruby)

22
Q

Carboplatin

A

Cross link DNA

23
Q

Irinotecan

A

Inhibit topoisomerase I (tucan)

24
Q

Bortezomib

A

Proteasome inhibitor, G2-M phase block

Multiple myeloma, mantle cell lymphoma

25
Q

Vinblastine

A

Binds beta tubulin, inhibits its polymerization

26
Q

Cladribine

A

Purine analog –> Inhibit DNA polymerase, Treats hairy cell leukemia (cave man in bear hide)

27
Q

Cetuximab

A

Monoclonal Ab against EGFR (tusks)

Head and neck, stage IV colorectal cancer (KRAS)

28
Q

Tamoxifen

A

SERM

29
Q

Cyclophosphamide

A

Alkylating agent (cyclops)

30
Q

Cytarabine

A

Pyrimidine analog –> Inhibit DNA polymerase (sabertooth tiger)

31
Q

Teniposide

A

Inhibit topoisomerase II (side of tower)

32
Q

5-fluorouracil

A

Pyrimidine analog –> Blocks thymidylate synthase

33
Q

Dactinomyin (actinomycin D)

A

Intercalates into DNA, childhood tumors (creepy doll)

Step pharm (9 decks)

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