Cancer drug Associations

Question 1

Erlotinib

Answer 1

EGFR tyrosine kinase inhibitor (earl)

Non small cell lung carcinoma

Question 2

Nitrosureas

Answer 2

Alkylating agent, brain tumors

Question 3

Etoposide

Answer 3

Inhibit topoisomerase II (side of tower)

Question 4

Paclitaxel, other taxanes

Answer 4

Hyperstabilize polymerized microtubules in M phase (tarzan)

Question 5

Busulfan

Answer 5

Alkylating agent, treatment before BMT (beautiful sirens)

Question 6

Bleomycin

Answer 6

Induce free radical formation DNA strands (whale)

Question 7

Topotecan

Answer 7

Inhibit topoisomerase I (tucan)

Question 8

Azathioprine, 6-mercaptopurine

Answer 8

Purine analog –> Blocks IMP synthesis

Question 9

Bevacizumab

Answer 9

Monoclonal Ab against VEGF (beverage lady)

Wet age related macular degeneration

Question 10

Vincristine

Answer 10

Binds beta tubulin, inhibit its polymerization (Tarzans girl)

Question 11

Hydroxyurea

Answer 11

Ribonucleotide reductase inhibitor (lady hitting hostess)

Question 12

Daunorubicin

Answer 12

Generates free radicals, Intercalate in DNA (ruby)

Question 13

Vemurafenib

Answer 13

BRAF inhibitor V600E-mutation (Ben Franklin Venom)

metastatic melanoma

Question 14

Methotrexate

Answer 14

Folic acid analog –> inhibits dihydrofolate reductase

Question 15

Cisplatin

Answer 15

Cross link DNA

Question 16

Ifosfamide

Answer 16

Alkylating agent

Question 17

Rituximab

Answer 17

Monoclonal Ab against CD20 (coronation ritual)

Question 18

Traztuzumab

Answer 18

Herceptin

Monoclonal Ab against HER-2

Question 19

Raloxifene

Answer 19

SERM

Question 20

Imatinib

Answer 20

Tyrosine kinase inhibitor of BCR-ABL (imitate)

CML, GIST

Question 21

Doxorubicin

Answer 21

Generates free radicals, Intercalate in DNA (ruby)

Question 22

Carboplatin

Answer 22

Cross link DNA

Question 23

Irinotecan

Answer 23

Inhibit topoisomerase I (tucan)

Question 24

Bortezomib

Answer 24

Proteasome inhibitor, G2-M phase block

Multiple myeloma, mantle cell lymphoma

Question 25

Vinblastine

Answer 25

Binds beta tubulin, inhibits its polymerization

Question 26

Cladribine

Answer 26

Purine analog --> Inhibit DNA polymerase, Treats hairy cell leukemia (cave man in bear hide)

Question 27

Cetuximab

Answer 27

Monoclonal Ab against EGFR (tusks) Head and neck, stage IV colorectal cancer (KRAS)

Question 28

Tamoxifen

Answer 28

SERM

Question 29

Cyclophosphamide

Answer 29

Alkylating agent (cyclops)

Question 30

Cytarabine

Answer 30

Pyrimidine analog --> Inhibit DNA polymerase (sabertooth tiger)

Question 31

Teniposide

Answer 31

Inhibit topoisomerase II (side of tower)

Question 32

5-fluorouracil

Answer 32

Pyrimidine analog --> Blocks thymidylate synthase

Question 33

Dactinomyin (actinomycin D)

Answer 33

Intercalates into DNA, childhood tumors (creepy doll)