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Neuro Flashcards

1
Q

Diazepam

A

Long acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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2
Q

Lorazepam

A

Long acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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3
Q

Triazolam

A

Short acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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4
Q

Temazepam

A

Short acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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5
Q

Oxazepam

A

Short acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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6
Q

Midazolam

A

Short acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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7
Q

chlordiazepoxide

A

Long acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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8
Q

Alprazolam

A

Short acting benzo

Use: SZ: alcohol withdrawal, sz status epilepticus SLEEP: insomnia, sleep walking, night terrors, muscle relaxant, PSYCH: GAD, panic disorder

MOA: Facilitate GABA-A action, increase opening frequency

SE: Dependence, tolerance, central ataxia, confusion, somnolence, anterograde amnesia

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9
Q

Short vs long acting benzo

A

Short acting: ATOM (alprazolam, triazolam, oxazepam, midazolam). Inactivated by liver

Long acting: active metabolites formed by liver

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10
Q

Phenobarbital

A

Barb

Use: Anxiety, sz, insomnia

MOA: Facilitate GABA-A by increasing opening duration. Long half live relative to bzd (hangover effect)

SE: Respiratory, cardiovascular depression, CNS depression, Dependence, INDUCE CYP450

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11
Q

Pentobarbital

A

Barb

Use: Anxiety, sz, insomnia

MOA: Facilitate GABA-A by increasing opening duration. Long half live relative to bzd (hangover effect)

SE: Respiratory, cardiovascular depression, CNS depression, Dependence, INDUCE CYP450

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12
Q

Thiopental

A

Barb

Use: Anesthesia induction, anxiety, sz, insomnia

MOA: Facilitate GABA-A by increasing opening duration. Long half live relative to bzd (hangover effect)

SE: Respiratory, cardiovascular depression, CNS depression, Dependence, INDUCE CYP450

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13
Q

Primidone

A

Barb

Use: essential tremor (with propanolol) sz (1 active metabolite is phenobarbital)

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14
Q

Bzd metabolism not in liver

A

OLT

Oxazepam, temazepam, and lorazepam are metabolized Outside The Liver

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15
Q

Zolpidem

A

Z drug, short acting

Use: Insomnia (initiation)

MOA: Bind GABA-A receptor (same spot as benzo). More specificity, less anxiolytic/antisz

SE: Cognitive impairment, delirium, central ataxia (less likely to cause dependence or tolerance)

DDI: alcohol, bzd, barbs, antihistamines

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16
Q

Zaleplon

A

Z drug, short acting

Use: Insomnia (initiation)

MOA: Bind GABA-A receptor (same spot as benzo). More specificity, less anxiolytic/antisz

SE: Cognitive impairment, delirium, central ataxia (less likely to cause dependence or tolerance)

DDI: alcohol, bzd, barbs, antihistamines

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17
Q

Eszopiclone

A

Z drug, long acting

Use: Insomnia (initiation and maintenance)

MOA: Bind GABA-A receptor (same spot as benzo). More specificity, less anxiolytic/antisz

SE: Cognitive impairment, delirium, central ataxia (less likely to cause dependence or tolerance)

DDI: alcohol, bzd, barbs, antihistamines

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18
Q

Flumazenil

A

Use: bzd/z drug od

MOA: GABA-A receptor antagonist at bzd site

SE: withdrawal induction

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19
Q

Ramelteon

A

Use: insomnia

MOA: Melatonin receptor MT1/MT2 agonist in SCN

SE: Dizziness, nausea, fatigue, HA (mild)

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20
Q

Desflurane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, malignant hyperthermia

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21
Q

Halothane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, HEPATOTOXIC, malignant hyperthermia

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22
Q

enflurane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, NEPHROTOXIC, SZ, malignant hyperthermia

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23
Q

Isoflurane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, malignant hyperthermia

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24
Q

Sevoflurane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, malignant hyperthermia

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25
Q

Methoxyflurane

A

Inhaled Anesthetic

MOA: unknown, GABA potenitation

SE: cardiac depression, respiratory depression, n/v, Increased ICP, malignant hyperthermia, NEPHROTOXIC

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26
Q

Inhaled Anesthetics Solubility

A

Less Soluble: faster onset, faster recovery

Blood gas partition coefficient = solubility

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27
Q

MAC definition and relation to potency

A

Alveolar concentration when 50% pt’s unresponsive

Potency=1/MAC

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28
Q

Dantrolene

A

Use: Malignant hyperthermia and NMS

MOA: RYR block

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29
Q

Opioid General Use, MOA, SE

A

Use: Pain, cough suppression, diarrhea, acute pulm edema, maintenance programs

MOA: Mew agonist –> post synaptic K open/ presynaptic Ca channel block

SE: n/v, respiratory depression, CNS depression, miosis, constipation, biliary colic (elevated lipase/amylase), tolerance, dependence, hyperalgias

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30
Q

Opioid withdrawal

A

rhinorrhea, lacrimation, yawning, hyperventilation, hyperthermia, muscle aches, vomiting, diarrhea, anxiety, mydriasis

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31
Q

Tramadol MOA

A

opiate

MOA: weak mew, strong blockade serotonin and NE

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32
Q

Loperamide use/moa

A

opiate

Use: diarrhea

MOA: increase phasic segmentation, doesn’t cross into blood

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33
Q

Diphenoxylate use/moa

A

opiate

Use: diarrhea

MOA: increase phasic segmentation, doesn’t cross into blood

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34
Q

Codeine

A

Opiate

Use: antitussive

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35
Q

Dextramethorphan

A

Opiate

Use: antitussive

MOA: mew agonist and NMDA antagonist

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36
Q

Methadone

A

Opiate

Use: abstinence maintenance

MOA: mew agonist extended serum half life, less addictive

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37
Q

Buprenorphine

A

Opiate

Use: Withdrawal treatment

MOA: Partial mew agonist, acts as mew antagonist if person already on opiate

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38
Q

Nalbuphine

A

Use: Withdrawal treatment

MOA: Partial mew agonist, acts as mew antagonist if person already on opiate

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39
Q

Butorphanol

A

Use: Withdrawal treatment

MOA: Partial mew agonist, acts as mew antagonist if person already on opiate

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40
Q

Naloxone

A

Use: Withdrawal treatment

MOA: Partial mew agonist, acts as mew antagonist if person already on opiate

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41
Q

Naltrexone

A

Use: Withdrawal treatment

MOA: Partial mew agonist, acts as mew antagonist if person already on opiate

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42
Q

SSRI/SNRI pharmacokinetics

A

Requires 1-2 months to reach max effect. Trials no less then 8-12 wks

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43
Q

Fluoxetine

A

SSRI

Use: Depression, Anxiety (PTSD, OCD, GAD, Panic disorder, Social anxiety), bulimia (last two not with SNRI)

MOA: Block 5-HT reuptake

SE: SIADH, sexual dysfunction, weight gain, flu like sx’s

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44
Q

Sertraline

A

SSRI

Use: Depression, Anxiety (PTSD, OCD, GAD, Panic disorder, Social anxiety), bulimia (last two not with SNRI)

MOA: Block 5-HT reuptake

SE: SIADH, sexual dysfunction, weight gain, flu like sx’s

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45
Q

Paroxetine

A

SSRI

Use: Depression, Anxiety (PTSD, OCD, GAD, Panic disorder, Social anxiety), bulimia (last two not with SNRI)

MOA: Block 5-HT reuptake

SE: SIADH, sexual dysfunction, weight gain, flu like sx’s

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46
Q

Citalopram

A

SSRI

Use: Depression, Anxiety (PTSD, OCD, GAD, Panic disorder, Social anxiety), bulimia (last two not with SNRI)

MOA: Block 5-HT reuptake

SE: SIADH, sexual dysfunction, weight gain, flu like sx’s, serotonin syndrome

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47
Q

serotonin syndrome

A

Hyperthermia, HTN, hyperreflexia, clonus

NMS has first two but also rigidity and hyporeflexia

Increased risk mixing SSRI, TCAD, MAO I

48
Q

Venlafaxine

A

SNRI

Use: Depression, GAD, diabetic neuropathy SOCIAL ANXIETY DISORDER, PANIC DISORDER, PTSD, OCD

SE: HTN, sedation, nausea

49
Q

Duloxetine

A

SNRI

Use: Depression, GAD, diabetic neuropathy, FIBROMYALGIA

SE: HTN, sedation, nausea

50
Q

Cyproheptadine

A

use: Serotonin syndrome treatment

MOA: 5-HT2 receptor antagonist

51
Q

Imipramine

A

TCAD

Use: 2nd/3rd line depression, nocturnal enuresis, peripheral neuropathy, migraine prophylaxis

MOA: 5-HT/NE reuptake inhibition (block NET/SRET), anticholinergic, H1 receptor blockade, alpha 1 antagonism, fast Na channel blockade

SE: Reduced libido, Sz, serotonin syndrome

Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention

Antihistamine: increased appetite, weight gain

Alpha 1: hypotension

Cardiotox: Decreased contractility, QRS widening, torsades

52
Q

Desipramine

A

TCAD

Use: 2nd/3rd line depression, peripheral neuropathy, migraine prophylaxis

MOA: 5-HT/NE reuptake inhibition (block NET/SRET), anticholinergic, H1 receptor blockade, alpha 1 antagonism, fast Na channel blockade

SE: Reduced libido, Sz, serotonin syndrome

Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention

Antihistamine: increased appetite, weight gain

Alpha 1: hypotension

Cardiotox: Decreased contractility, QRS widening, torsades

53
Q

Clomipramine

A

TCAD

Use: 2nd/3rd line depression, OCD, peripheral neuropathy, migraine prophylaxis

MOA: 5-HT/NE reuptake inhibition (block NET/SRET), anticholinergic, H1 receptor blockade, alpha 1 antagonism, fast Na channel blockade

SE: Reduced libido, Sz, serotonin syndrome

Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention

Antihistamine: increased appetite, weight gain

Alpha 1: hypotension

Cardiotox: Decreased contractility, QRS widening, torsades

54
Q

Amitriptyline

A

TCAD

Use: 2nd/3rd line depression, peripheral neuropathy, migraine prophylaxis

MOA: 5-HT/NE reuptake inhibition (block NET/SRET), anticholinergic, H1 receptor blockade, alpha 1 antagonism, fast Na channel blockade

SE: Reduced libido, Sz, serotonin syndrome

Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention

Antihistamine: increased appetite, weight gain

Alpha 1: hypotension

Cardiotox: Decreased contractility, QRS widening, torsades

55
Q

Nortriptyline

A

TCAD

Use: 2nd/3rd line depression, peripheral neuropathy, migraine prophylaxis

MOA: 5-HT/NE reuptake inhibition (block NET/SRET), anticholinergic, H1 receptor blockade, alpha 1 antagonism, fast Na channel blockade

SE: Reduced libido, Sz, serotonin syndrome

Anticholinergic: Dry mouth, constipation, blurred vision, urinary retention

Antihistamine: increased appetite, weight gain

Alpha 1: hypotension

Cardiotox: Decreased contractility, QRS widening, torsades

56
Q

TCAD arrhythmia treatment

A

NaHCO3

57
Q

Tranylcypromine

A

MAO I

Use: Atypical depression

MOA: MAO-A/B blockade increasing dopamine, NE, serotonin

SE: weight gain, severe sexual dysfunction, HTN crisis w/ tyramine ingestion

58
Q

phenelzine

A

MAO I

Use: Atypical depression

MOA: MAO-A/B blockade increasing dopamine, NE, serotonin

SE: weight gain, severe sexual dysfunction, HTN crisis w/ tyramine ingestion

59
Q

Isocarboxazid

A

MAO I

Use: Atypical depression

MOA: MAO-A/B blockade increasing dopamine, NE, serotonin

SE: weight gain, severe sexual dysfunction, HTN crisis w/ tyramine ingestion

60
Q

Selegiline

A

MAO I

Use: Parkinsons

MOA: MAO-B blockade Increasing dopamine in the brain

61
Q

HTN crisis and tyramine

A

tyramine broken down in GI tract by MAO-A

If block MAO-A, moves into circulation displacing NE from neuronal storage vesicles

62
Q

HTN crisis treatment

A

Phentolamine, phenoxybenzamine

63
Q

Buproprion

A

Use: depression w/ decreased energy, tobacco dependence

MOA: Inhibit dpamine/NE reuptake (NET/DAT)

SE: Sz (greatest w/ eating disorders), NO SEXUAL DYSFUNCTION, weight loss

64
Q

Mirtazapine

A

Use: Depression w/ insomnia

MOA: presynaptic alpha 2 inhibition –> Increased NE/serotonin. 5-HT2/3 antagonism, H1 receptor antagonism

SE: sedation, weight gain, NO SEXUAL DYSFX

65
Q

Trazodone

A

Use: Insomnia and major depression

MOA: antagonize post synaptic 5-HT2, weakly inhibit serotonin reuptake. alpha 1 and H1 receptor blockade

SE: priapism, hypotension, sedation, sexual dysfx, serotonin syndrome

66
Q

Varenicline

A

Use: smoking cessation

MOA: Nicotinic ach partial agonist

SE: sleep disturbance, depressed mood

67
Q

ADHD First Line

A

Stimulants (methylphenidate, amphetamines)

68
Q

Alcohol withdrawal First Line

A

Bzd (chlordiazepoxide, lorazepam, diazepam)

69
Q

Bipolar disorder First Line

A

Lithium, valproate, carbamazepine, lamotrigine, atypical antipsychotics

70
Q

Bulimia First Line

A

SSRI

71
Q

Depression First Line

A

SSRI

72
Q

GAD First Line

A

SSRI, SNRI

73
Q

OCD First Line

A

SSRI, Venlafaxine, clomipramine (TCAD)

74
Q

Panic Disorder First Line

A

SSRI, venlafaxine, bzd

75
Q

PTSD First Line First Line

A

SSRI, venlafaxine

76
Q

Schizophrenia First Line

A

Atypical antipsychotics

77
Q

SAD First Line

A

SSRI, venlafaxine

performance only: beta blockers, bzd

78
Q

tourette syndrome First Line

A

antipsychotics (fluphenazine, pimozide), tetrabenazine

79
Q

Lithium

A

Use: Bipolar disorder (acute mania and maintenance)

MOA: Not established, possible inhibition phosphinositol cascade

SE: Reversible thyroid dysfx, nephrogenic DI, acute n/v/diarrhea, chronic tremor/confusion/ataxia, teratogen (ebsteins anomaly)

DDI: Thiazides, NSAID’s decrease elimination

80
Q

Bipolar disorder medications

A

Mania and Maintenance: carbamazepine, valproate, lithium

Acute mania: antipsychotics

Maintenance: lamotrigine

81
Q

Valproate

A

Broad spec Antiepileptic

Use: Broad Spectrum sz, juvenile myoclonic epi, absence

MOA: Extend inactive phase voltage gated Na channels. Increase GABA (either increase production or decrease degradation)

SE: n/v, increased appetite, weight gain, tremor, hepatotoxic, acute pancreatitis, teratogen (NTD), CYP450 METABOLIZED

82
Q

Topiramate

A

Broad spec Antiepileptic

Use: Broad spec sz, juvenile myoclonic epi, possible absence

MOA: Extend inactive phase voltage gated Na channels, allosterically bind and potentiate GABA-A

SE: fatigue, somnolence, cognitive slowing, weight loss, urolithiasis, acute myopia, acute angle glaucoma, CYP450 METABOLIZED

83
Q

Lamotrigine

A

Broad spec Antiepileptic

Use: Broad spec sz, juvenile myoclonic epi, absence

MOA: Increase Na channel inactivation

SE: SJS, skin rash, diplopia, CYP450 METABOLIZED

84
Q

Levitiracetam

A

Broad spec Antiepileptic

Use: Broad spec sz, juvenile myoclonic epi

SE: Somnolence, CYP450 METABOLIZED

85
Q

Carbamazepine

A

Narrow spec antiepi

Use: Focal sz, generalized sz (worsen other sz disorders), trigeminal neuralgia

MOA: Extend inactivation voltage gated Na channels

SE: diplopia, ataxia, DRESS syndrome, SJS (HLAB1502 asians), teratogen (NTD), SIADH, leukopenia, agranulocytosis, CYP450 INDUCER

86
Q

Phenytoin

A

Narrow spec antiepi

Use: Focal sz, generalized sz (worsen other sz disorders)

MOA: Extend inactivation voltage gated Na channels

SE: nystagmus, diplopia, ataxia, DRESS syndrome, SJS (HLAB1502 asians), teratogen (cleft palate), low folate, gingival hyperplasia, hirsutism, drug induced lupus, altered bone metabolism and decreased bone density, CYP450 INDUCER

87
Q

Gabapentin/pregabalin

A

Narrow spec antiepi

Use: focal sz add on, postherpatic neuralgia (VZV), diabetic neuropathy, fibromyalgia

MOA: bind/block voltage gated Ca channel, inhibit inward Ca current

SE: dizziness, sedation, ataxia

88
Q

Vigabatrin

A

Use: Narrow spec antiepi

MOA: irreversible inhibitor GABA transaminase, increase GABA CNS

89
Q

Tiagabine

A

Use: Narrow spec antiepi

MOA: Inhibit GABA reuptake

90
Q

Status epilepticus treatment

A

Initial: IV diazepam or lorazepam

Maintenance: IV phenytoin

Not responsive: IV phenobarbital

91
Q

Ethosuximide

A

Absence

Use: Absence sz (3 hz spike wave complexes EEG), no other sz treatment

MOA: Block T-type Ca channels of thalamus

SE: n/v, abd pain, fatigue

92
Q

Absence sz treatment

A

ethosuximide, valproate, lamotrigine

93
Q

Haloperidol

A

High potency first gen antipsychotic

94
Q

Trifluoperazine

A

High potency first gen antipsychotic

95
Q

Fluphenazine

A

High potency first gen antipsychotic

96
Q

First gen high potency antipsychotics

A

Use: Schizophrenia + sx’s, psychotic mania, MDD w/ psychosis, delirium, tourettes

MOA: high postsynaptic D2 receptor block CNS (mesolimbinc & striatal frontal)/ low anticholinergic, H1, and anti alpha 1 blockade

SE: High: EPS (acute dystonia, akathisia, parkinsonism), tardive dyskinesia, prolactinemia, NMS (lead pipe rigidity, AMS, fever, autonomic instability, rhabdo)

Low: anticholinergic (dry mouth, blurred vision, constipation, urinary retention) alpha 1 (orthostatic hypotension, tachy), H1 (sedation)

Equal: QT prolongation, torsades, sz

97
Q

Chlorpromazine

Unique SE

A

Low potency first gen antipsychotic

Unique SE: lens and corneal deposits

98
Q

Thioridazine

Unique SE

A

Low potency first gen antipsychotic

Unique SE: Retinal deposits

99
Q

First gen low potency antipsychotics

A

Use: Schizophrenia + sx’s, psychotic mania, MDD w/ psychosis, delirium, tourettes

MOA: Low postsynaptic D2 receptor block CNS (mesolimbinc & striatal frontal)/ high anticholinergic, H1, and anti alpha 1 blockade

SE: Low: EPS (acute dystonia, akathisia, parkinsonism), tardive dyskinesia, prolactinemia, NMS (lead pipe rigidity, AMS, fever, autonomic instability, rhabdo)

High: anticholinergic (dry mouth, blurred vision, constipation, urinary retention) alpha 1 (orthostatic hypotension, tachy), H1 (sedation)

Equal: QT prolongation, torsades, sz

100
Q

2nd gen antipsychotics

A

Use: schizophrenia (+ & - sx’s), treatment resistance depression, bipolar, OCD (w/ SSRI), tourette’s (risperidone)

MOA: Low D2 receptor blockade/high 5-HT2A receptor block

SE: H1 block (drowsiness), alpha 1 block (hypotension, tachy), anticholinergic (dry mouth, constipation, blurred vision, urinary retention), Metabolic (weight gain, dyslipidemia, hyperglycemia), Neutropenia, lower sz threshold, EPS, NMS, QT prolongation, torsades

101
Q

Clozapine

A

SGA

Unique SE: agranulocytosis, myocarditis, cardiomyopathy, anticholinergic

High SE: H1 block, Metabolic (weight gain, dyslip, hyperglycemia)

102
Q

Quetiapine

A

SGA

High SE: H1 block

103
Q

Olanzapine

A

SGA

High SE: metabolic

104
Q

Risperidone

A

SGA

High: EPS, prolactinemia

105
Q

Aripiprazole

A

SGA

106
Q

Ziprasidone

A

SGA

107
Q

Levodopa

A

Parkinsons drug

MOA: Dopamine precursor that crosses BBB

SE:
peripheral dopamine: n/v, tachy, arrhythmia, a fib, ortho hypotension

CNS dopamine: Anxiety, agitation, confusion, hallucination, insomnia

Long term: Therapeutic window narrows, wearing off effect w/ dyskinesia in off period

contraindicated psych patients

108
Q

Carbidopa

A

Parkinsons drug

MOA: peripheral dopa decarboxyalse inhibitor

109
Q

Entacapone

A

Parkinsons drug

Use: Only effective as add on to L dopa

MOA: Peripheral COMT inhibitor (prevent conversion of dopamine to 3-O-methyldopa

110
Q

Tolcapone

A

Parkinsons drug

Use: Only effective as add on to L dopa

MOA: peripheral and central COMT inhibitor (Prevent conversion dopamine to 3-O-methyldopa or 3-MT)

SE: hepatic failure

111
Q

Selegiline

A

Parkinsons drug

use: Adjunctive agent to L-dopa

MOA: MAO-B inhibitor

SE: enhance L-dopa SE,

112
Q

Ropinirole

A

Parkinson’s drug

use: First line therapy, restless leg syndrome

MOA: D2 receptor agonist

SE: Similar L-dopa, more sever psych (rock & roll)

113
Q

Pramipexole

A

Parkinson’s drug

use: First line therapy, restless leg syndrome (rock and roll)

MOA: D3 receptor agonist

SE: similar L-dopa, more severe psych

114
Q

Amantadine

A

Parkinson’s drug

MOA: Increase dopamine synthesis and release, inhibit reuptake

115
Q

Benztropine

A

Use: Parkinson’s tremor and rigidity, no effect bradykinesia

MOA: Central acting antimuscarinic (park unbalanced high levels ACH)

116
Q

Trihexyphenidyl

A

Use: Parkinson’s tremor and rigidity, no effect bradykinesia

MOA: Central acting antimuscarinic (park unbalanced high levels ACH)

Step pharm (9 decks)

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