Cancer Drugs MOAs and AEs Flashcards Preview

Pulmonary Week 3 > Cancer Drugs MOAs and AEs > Flashcards

Flashcards in Cancer Drugs MOAs and AEs Deck (23):
1

Carboplatin/Cisplatin

Forms DNA intrastrand crosslinks and adducts

2

Cyclophosphamide/Ifosfamide

Pro-drug of active alkylating moiety

3

Docetaxel/Paclitaxel

Microtubule stabilizer inhibiting depolymerization

4

Doxorubicin

Intercalator, free radical generator, too II inhibitor

5

Etoposide, VP-16

DNA-topo II complex stabilizer

6

Gemcitabine

DNA polymerase inhibitor via incorporation of triphosphate form during DNA synthesis

7

Irinotecan/Topotecan

DNA-topo I complex stabilizer

8

Pemetrexad

DHFR Inhibitor

9

Vincristine/Vinorelbine

Microtubule inhibitor; tubules disintegrate into spiral aggregates/ protofilaments

10

Which is more toxic, Cisplatin or Carboplatin?

Cisplatin

11

Toxicities of Carboplatin/Cisplatin?

-**Nephro and ototoxicity (dose-limiting toxicity)
-peripheral neuropathy (more in cisplatin- numbness in distal extremities)

12

What drug is often given with Carboplatin/Cisplatin to prevent nephrotoxicity?

Amifostine

13

AEs of Cyclophosphamide /Ifosfamide

Hemorrhagic cystitis from acrolein

14

AEs of Docetaxel/Paclitaxel

-hypersensitivity
-diarrhea
-mucositis
-peripheral neuropathy

15

AEs of Doxorubicin?

-red-orange urine
-chronic cardiomyopathy and CHF from free radicals
-cardiac arryhthmias

16

How are the CV AEs of Doxorubicin avoided?

Dexrazoxane

17

AEs of Etoposide, VP-16

-hypotension
-hypersensitivity
-N/V

18

AEs of Gemcitabine?

-interstitial pneumonitis
-mucositis
-diarrhea

19

AEs of Irinotecan/Topotecan?

-asthenia
-N/V

20

AEs of Pemetrexed?

-hepatic fibrosis
-pneumonitis
-mucositis
-diarrhea

21

What drug is given to prevent the toxicities of Pemetrexed?

Leucovorin

22

AEs of Vinblastine/Vinorelbine?

-SIADH with vincristine
-constipation
-peripheral neuropathy

23

Two other drugs associated with peripheral neuropathy?

bortezomib and thalidomide