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Flashcards in Pulmonary Infections Deck (21):
1

Pneumonia is infection of what part of the lung?

parenchyma

2

What are the three histological patterns of pneumonia?

Bronchopneumonia (patchy)

Lobar pneumonia/ typical
pneumonia (entire lobe or portion of a lobe)

Interstitial (atypical) pneumonia

3

What is a big IVDU cause of pneumonia?

Staph aureus

4

What are the stages of inflammatory response in pneumonia?

-congestion
-red hepatization
-gray hepatization
-resolution

5

What is the congestion phase of inflammatory response to pneumonia characterized by?

vascular engorgemnet and edema, few PMNs, and numerous bacteria

6

What is the red hepatizationphase of inflammatory response to pneumonia characterized by?

Masive congestion, and abundant PMNs and fibrin

7

What is the grey hepatizationphase of inflammatory response to pneumonia characterized by?

Disintegration of RBCs and macrophages, Fibropurulent exudate

8

What is the resolution phase of inflammatory response to pneumonia characterized by?

Enzymatic digestion and resolution by macrophages

9

What pneumonia sources cause necrotizing pneumonia (e.g. can cause abscess formation)?

streptococcus, Klebsiella

10

When pneumonia causing bacteria spread to the pleural cavity, it is called ____

emphyema

11

How is atypical pneumonia different?

-less sputum production
-neutrophilic alveolar exudate typically lacking

12

How does Legionella transmission typically occur?

Naturally in the environment, usually in water (grow best in warm water, like the kind found in cooling tanks)

Not spread from one person to another person

13

What does Legionella require to grow?

cysteine and iron (doesn't grow on BAP)

14

How does Legionella present histologically?

Extensive bronchopneumonia to lobar pneumonia with intra-alveolar neutrophils, macrophages, fibrin; often with leukocytoclastic neutrophilic infiltrate, small vessel vasculitis and necrosis

15

Aspiration pneumonia presents where most commonly?

right lower lobe due to the anatomy of the lungs and bronchi

16

What is a good indication of aspiration pneumonia on H&E?

foreign body giant cells

17

Primary TB is more commonly found in what part of the lung?

lower (2ndary more common in the apex)

18

What is a good indication of TB on H&E?

langhans giant cells and caveating granulomas

19

How does Mycobacterium tuberculosis organisms, many of which are present within macrophages, appear as with an acid fast stain?

red rods

20

Which fungal pneumonia commonly produces granulomas?

Histoplasmosis

21

Which cause of pneumonia gives the characteristic 'owl's eyes' appearance?

CMV pneumonia