Flashcards in Pulmonary Infections Deck (21):
Pneumonia is infection of what part of the lung?
What are the three histological patterns of pneumonia?
Lobar pneumonia/ typical
pneumonia (entire lobe or portion of a lobe)
Interstitial (atypical) pneumonia
What is a big IVDU cause of pneumonia?
What are the stages of inflammatory response in pneumonia?
What is the congestion phase of inflammatory response to pneumonia characterized by?
vascular engorgemnet and edema, few PMNs, and numerous bacteria
What is the red hepatizationphase of inflammatory response to pneumonia characterized by?
Masive congestion, and abundant PMNs and fibrin
What is the grey hepatizationphase of inflammatory response to pneumonia characterized by?
Disintegration of RBCs and macrophages, Fibropurulent exudate
What is the resolution phase of inflammatory response to pneumonia characterized by?
Enzymatic digestion and resolution by macrophages
What pneumonia sources cause necrotizing pneumonia (e.g. can cause abscess formation)?
When pneumonia causing bacteria spread to the pleural cavity, it is called ____
How is atypical pneumonia different?
-less sputum production
-neutrophilic alveolar exudate typically lacking
How does Legionella transmission typically occur?
Naturally in the environment, usually in water (grow best in warm water, like the kind found in cooling tanks)
Not spread from one person to another person
What does Legionella require to grow?
cysteine and iron (doesn't grow on BAP)
How does Legionella present histologically?
Extensive bronchopneumonia to lobar pneumonia with intra-alveolar neutrophils, macrophages, fibrin; often with leukocytoclastic neutrophilic infiltrate, small vessel vasculitis and necrosis
Aspiration pneumonia presents where most commonly?
right lower lobe due to the anatomy of the lungs and bronchi
What is a good indication of aspiration pneumonia on H&E?
foreign body giant cells
Primary TB is more commonly found in what part of the lung?
lower (2ndary more common in the apex)
What is a good indication of TB on H&E?
langhans giant cells and caveating granulomas
How does Mycobacterium tuberculosis organisms, many of which are present within macrophages, appear as with an acid fast stain?
Which fungal pneumonia commonly produces granulomas?