cancer genes/markers Flashcards Preview

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Flashcards in cancer genes/markers Deck (46):
1

BCR-ABL

oncogene. t(9,22). tyrosine kinase. defines CML, found in some ALL

2

BCL-2

oncogene. t(14,18). antiapoptotic molecule that prevents cytochrome c from leaking out. follicular and undifferentiated lymphomas

3

BRAF

oncogene. serine/threonine kinase. melanoma, NH lymphoma

4

c-kit

oncogene. pt. mutation. cytokine receptor - stem cell GFR. GIST

5

c-myc

oncogene. t(8,14). transcription factor. burkitts

6

HER2/neu

oncogene. amplification. tyrosine kinase - epidermal GFR. breast, ovarian, gastric CA

7

L-myc

oncogene. amplification. transcription factor. Lung tumor - small cell

8

N-myc

oncogene. amplification. transcription factor. Neuroblastoma

9

RAS

oncogene. pt mutation. GTPase. colon, lung, pancreatic, lymphoma, melanoma.

10

RET

oncogene. pt mutation. tyrosine kinase - neural GFR. MEN 2a + 2b, medullary thyroid CA

11

PGDFB

oncogene. growth factor. overexpression -> autocrine loop -> astrocytoma.

12

CCND1

oncogene. t(11,14). cyclin D1. mantle cell lymphoma

13

CDK4

oncogene. amplification. cyclin-dependent kinase. melanoma

14

APC

tumor suppressor gene. colorectal CA (associated w/FAP)

15

BRCA1/2

tumor suppressor gene. breast and ovarian. DNA repair protein

16

DCC

tumor suppressor gene. colon: Deleted in Colon Cancer

17

DPC4/SMAD4

tumor suppressor gene. pancreatic CA. Deleted in Pancreatic Cancer

18

MEN1

tumor suppressor gene. menin.

19

NF1

tumor suppressor gene. Ras GTPase activating protein (neurofibromin)

20

NF2

tumor suppressor gene. merlin (schwannomin) protein

21

p16

tumor suppressor gene. melanoma. cyclin-dependent kinase inhibitor 2A

22

p53

tumor suppressor gene. most human CA. 1 copy missing in Li-Fraumeni. transcription factor for p21, blocks G1->S phase

23

PTEN

tumor suppressor gene. breast, prostate, endometrial

24

Rb

tumor suppressor gene. retinoblastoma, osteosarcoma. binds E2F (a transcription factor), preventing G1->S phase

25

TSC1

tumor suppressor gene. tuberous sclerosis. hamartin protein

26

TSC2

tumor suppressor gene. tuberous sclerosis. tuberin protein

27

VHL

tumor suppressor gene. von Hippel Lindau, renal cell CA. inhibits hypoxia inducible factor 1a

28

WT1/WT2

tumor suppressor gene. Wilms Tumor (nephroblastoma)

29

alk phos

bone/liver mets, paget dz of bone, seminoma (placental ALP)

30

AFP

HCC, hepatoblastoma, yolk sac (endodermal sinus) tumor mixed germ cell tumor. normally made by fetus. transiently elevated in pregnancy.

31

beta-hCG

hydatidiform moles and choriocarcinomas, testicular CA, mixed germ cell tumor. produced by syncytiotrophoblasts

32

CA15-3/CA27-29

breast CA

33

CA19-9

pancreatic adenoCA

34

CA125

ovarian CA

35

calcitonin

medullary thyroid CA

36

CEA

CarcinoEmbryonic Ag. nonspecific. ~70% of colorectal and pancreatic CA. also breast, gastric, medullary thyroid CA

37

chromogranin

neuroendocrine tumors/carcinoid

38

PSA

prostate CA. also BPH and prostatisis

39

EBV

burkitt, H lymphoma, nasopharyngeal CA, primary CNS lymphoma (in immunocompromised)

40

HBV, HCV

HCC

41

HHV-8

kaposi (AIDS: antiretrovirals, transplant: dec. suppression, old eastern euro man: excision).

42

H. pylori

gastric adenocarcinoma, MALT lymphoma

43

HTLV-1

adult T-cell leukemia/lymphoma

44

liver fluke (clonorchis sinensis)

cholangiocarcinoma

45

schistosoma haematobium

bladder CA (squamous cell)

46

CAs w/psammoma bodies

PSaMMoma! Papillary CA of thyroid, Serous papillary cystadenocarcinoma of the ovary, Meningioma, Malignant mesothelioma