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Flashcards in heme/onc Deck (26):
1

vWF receptor

GpIb

2

fibrinogen receptor on plts

GpIIb/IIIa

3

plt dense granules

ADP, Ca

4

plt alpha granules

vWF, fibrinogen

5

neutrophil granule contents

ALP, collagenase, lysozyme, lactoferrin.

6

azurophilic neurophil granule contents

proteinases, acid phosphatase, myeloperoxidase, beta-glucuronidase

7

hypersegmented PMNs

5+ lobes. seen in B12/folate def.

8

neutrophil chemotactic agents

C5a, IL-8, LTB4, kallikrein, plt-activating factor

9

monocyte histo

large, kidney-shaped nucleus. lots of "frosted-glass" cytoplasm

10

lipid A

from bacterial LPS. binds CD14 on macrophages -> shock

11

causes of eosinophilia

NAACP: neoplasia, asthma, allergic processes, chronic adrenal insufficiency, parasites (invasive)

12

basophilia

rare. can be a sign of CML

13

basophils

mediate allergic rxn. granules contain heparin + histamine. synthesize + release leukotrienes on demand

14

dendritic cell

highly phagocytic APC. link between innate + adaptive immunity. = langerhans in skin.

15

CD28

necessary costimulatory signal for T cell activation

16

bradykinin regulators

kallikrein activates, ACE inactivates

17

target of warfarin

vit K epoxide reductase

18

factor V leiden

factor V is resistant to inhibition by activated protein C

19

2 processes of fibrinolysis

1. cleavage of fibrin mesh. 2. destruction of coagulation factors

20

endothelial response to injury

transient vasocontriction via neural stim reflex + endothelin released from damaged cells

21

step 2 of primary hemostasis

exposure: vWF (from WP bodies and plt alpha-granules) binds exposed collagen

22

step 3 of primary hemostasis

adhesion: plts bind vWF at site of injury (only), conformational change, release ADP (helps plts adhere) + Ca (necessary for coag cascade) + TXA2

23

step 4 of primary hemostasis

activation: ADP binds receptor, induces GpIIb/IIIa receptor expression on plt surface

24

step 5 of primary hemostasis

aggregation: fibrinogen binds GpIIb/IIIa receptor + links plts. temporary plug stops bleeding

25

pro-aggregation factors

TXA2, dec. blood flow, inc. plt aggregation

26

anti-aggregation factors

PGI2 + NO (both released by endothelial cells), inc. blood flow, dec. plt aggregation