Cancer Immunolgy Flashcards
(6 cards)
1
Q
Describe how cancers are immunogenic
A
- T-cells, natural killer cells and macrophages surround tumours
- Infiltrate is independent of infection and necrosis
- Pro-inflammatory cytokine effect
- Spontaneous Regression
2
Q
What are some tumour antigens ?
A
• Mutated proteins
•Unmutated proteins but not normally expressed
•Viral proteins
Tumours are self tissue but:
•Altered Carbohydrates
•Altered Lipids
3
Q
What can tumour antigens differ between ?
A
1.different tumours
2. Tumours and normal tissue
4
Q
How are tumour antigens classified ?
A
- Tumour specific antigens
- Tumour associated antigens
5
Q
What can monoclonal antibodies recognise ?
A
- Increased amounts of antigen
eg CALLA/CD10 - Presence of antigen in an abnormal site eg Cytokeratin
6
Q
How do tumours evade the immune system ?
A
- Immunosuppression
- Tumour Infiltrating cells
