IPS Cell Development

Question 1

Define Pluripotency

Answer 1

indicates the
potential of a stem cell to differentiate into cell types that originate
from all of the 3 germ layers of the embryo

Question 2

Define induced pluripotency

Answer 2

relates to this quality or
characteristic being induced in a cell type
that does not normally have it

Question 3

Decribe the conclusion of Yamanka & Gurdon’s research

Answer 3

data demonstrates that iPS cells can be induced from MEF culture by the
introduction of four transcription factors,
Oct3/4, Sox2, c-Myc, and Klf4

Question 4

Describe Human embryonic stem cells

Answer 4

• first isolated in the laboratory in the late 90s
• They were taken from the inner cell mass of blastocysts
• The usual source is remainders from fertility treatment.
• They have a high proliferative capacity and can potentially be maintained indefinitely in the correct culture
  environment.