Cancer Pharmacology Flashcards
(29 cards)
Drugs that inhibit DNA synthesis
Doxorubicin (intercalater, radicals, topo ii), Etoposide (topoII), Gemcitabine, Irinotecan, Topotecan (topoI)
Drugs that affect existing DNA
Carboplatin, Cisplatin (crosslinks), Cyclophosphamide, Ifosfamide (alkylators)
Drugs that inhibit microtubules
Docetaxel, Paclitaxel (inhibit depolymerization), Vincristine, Vinorelbine
Ameliorates Cisplatin toxicity
Amifostine
Ameliorates Doxorubicin toxicity
Dexrazoxane
Ameliorates Cyclophosphamide and Ifosfamide toxicity
MESNA (protects from acrolein)
Dose limiting toxicity of Cisplatin
Nephro and Ototoxicity
Dose limiting toxicity of Doxorubicin
Cardiotoxicity
Chemotherapy-induced peripheral toxicity from what drugs
Taxanes (Docetaxel, Paclitaxel); Vinka alkaloids (Vincristine, Vinorelbine); and Platins (Cisplatin more than Carboplatin)
Which drugs target EGFR del19/21subs
Afatinib, Erlotinib, Gefitinib
Which drugs target ALK
Alectinib, Ceritinib, Crizotinib (also HGFR mutation)
Which drugs target VEGF or VEGFR
Bevacizumab (VEGF) and Ramucirumab (VEGFR)
Which drugs target PD-1
Nivolumab and Pembrolizumab
Which drugs target EGFR
Necitumumab and Panitumumab
What drug targets EGFR-T790M mutation
Osimertinib (most common mutation in TKs)
How do mabs work
IV infusion and kill by ADCC, CDC, and initiation for apoptosis
What CYP metabolizes TKIs
CYP3A4 (Imatinib mod inhibitor) some P-glycoproteins
What drug targets BRAF V600E mutations
VEMURAFENIB, DABRAFENIB, and TRAMETINIB
EGFR TKIs have what common adverse effect (other TKIs to lesser degree)
Rash (treat with steroid, sunscreen, antimicrobial)
VEGF targeted therapies have what side effects
Bleeding (Bevacizumab), Increased thrombosis, CV toxicity, and hypertension
PD-1 inhibitors have what side effects
Rash, GI toxicity, Liver toxicity, and ENDOCRINOPATHIES
Targeted therapies treat what type of cancer
Adenocarcinoma
Most common mutation in non-smokers
KRAS
What genetic testing is indicated in adenocarcinoma
EGFR and ALK
