Viral Pulmonary Drugs

Question 1

Acyclovir, valacyclovir, and cidofovir MOA

Answer 1

Inhibition of viral DNA synthesis (DNA polymerase inhibition)

Question 2

Amantadine and Rimantadine MOA

Answer 2

Inhibition of viral entry or uncoating

Question 3

Oseltamavir and Zanamivir MOA

Answer 3

Inhibition of release of influenza virus from infected cell

Question 4

Zanamivir adverse reactions

Answer 4

Headache, throat/tonsil pain, cough, viral infection

NOT to be used w/underlying pulmonary disease – fatal bronchospasm

Question 5

Ribavirin adverse reactions

Answer 5

Most commonly fatigue, headache, myalgia, nausea, fever

BLACK BOX warnings for hemolytic anemia & M/F teratogenicity

Question 6

Acyclovir adverse reactions

Answer 6

Headache, nausea, neurotoxicity (confusion, seizures)
Maintain hydration to prevent renal precipitation
Use cautiously in renal impairment or with reno-toxic drugs

Question 7

Cidofovir adverse reactions

Answer 7

Multiple adverse effects including neurologic, hematologic & tubular damage
BLACK BOX warning for renal impairment/toxicity

Question 8

Oseltamavir adverse reactions

Answer 8

Minimal adverse effects
Potential for fatal neuropsychiatric adverse effects in flu patients; serious skin
reaction reported rarely