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Flashcards in Candida albicans Deck (31):
1

Candida albicans is what type of infection?

Fungal

2

Candida albican is what type of pathogen?

Opportunistic pathogen

3

Candida albicans are common species of what?

Normal flora

4

Candida albicans can overgrow after what?

after antibiotic treatment

5

Candidasis thrush is an infection where?

in mouth

6

Invasive (severe) candida albicans can cause what type of infections?

Systemic blood infections

7

Vaginitis is an infection where?

Vaginal infection

8

Vaginitis is also called what?

Yeast infection

9

Vaginitis is characterized by what?

- white or yellow discharge

-burning or itching

-inflamation of vagina and vulva

10

The yeast form of C. albicans that cause vaginitis can grow as what?

fungi called pseudophyphae

11

How is vaginitis diagnosed?

Swab samples from vaginal infection?

12

what % woman experience vaginitis at least once in their lifetime ?

75%

13

Vaginitis causes alterned normal flora of what?

lactobacilli

14

Yeast colonizes what surfaces?

mucosal surfaces

15

Hyphae colonize what surfaces?

Invades host tissues and mucosal epithelial cell layers; breaches endothelial cells.

16

Yeast can dissemination (spread) where in immunocompromised host?

into host tissues

17

Pseudohyphae hae what type of motility?

De facto motility

18

Pseudohyphae have what type of nutritional scavenging compared to yeast?

Enhanced nutrient scavenging compared to yeast

19

Hyphae can causes lysis to what?

macrophages and neutrophilis

20

Hyphae have thigmotropism which is what?

The bending or turning of the organism in response to a touch stimulus

21

hyphae have what antigen?

Have antigen variation

22

Can candida albicans grow as a biofilm?

yes

23

Candida albicans biofilm infections are often asociated with what?

medical devices

24

What is the treatment for Candida albican non invasive infections?

fluconazole

25

What is the treatment for systemic Candida albicans infection

amphotericin B

26

Resistance mechanisms of Candida albican are similar to what? How?

bacteria; biofilm-specific gene expression, biofilm matrix, and efflux

27

What adhesion proteins does candida albican have?

-AIs1p, AIsp, Hwp1p, Int1p

28

What are the virulence factors of candida albican?

1) Adhesion proteins
2) Morphogenesis into invasive filaments
3)degradative enzymes
4) Phenotypic switching

29

What are the degradation enzymes of candida albican?

-various proteinases,
-aspartyl protease
-phospholipases

30

Phenotypical switching plays a role in what?

-altering yeast's adherence properties
-antigen expression
-tissue affinity

31

Phenotypical switching helps in what?

adaption