cannabinoids Flashcards
(24 cards)
key psychoactive substances in cannabis
- THC
- CBD
- trichomes (high THC)
CBD
does not produce intoxicating effects
- may counteract THC effects
cannabis indica
- short leaves
- sedative effects
- balanced THC: CBD
cannabis sativa
- tall/thin leaves
- uplifting + energizing
-high THC: CBD
cannabis ruderalis
- small hardy
- minimal psychoactive effects
- used in crossbreading
historical use of cannabis
- China: earliest use
- India: rituals/medicine
- Egypt: ritualistic/medicinal
- Arabia: recreational/medicinal
- Europe: hemp and medicinal
- NA: ropes + textiles
what act legalized cannabis in canada?
cannabis act bill C45
marijuana
dried cannabis flowers, leaves, and stems for smoking
hashish
condensed, hardened dried trichome resins
- higher THC
- hash oil even higher THC
joints
hashish or marijuana rolled into cigarette for smoking
- 6-20% THC
bongs
bowl with water chamber and mouthpiece for inhalation
dabs
inhaling vapours from flame-heated hashish oil and butane mixture
- up to 80% THC
what is a common side effect of edibles?
overconsumption due to delayed effects
vapes
devices use to heat cannabis oil without harmful combustion
- THC levels over 90%
THC unit in canada
5mg
absorption of THC
inhalation and oral
metabolism of THC
P450 enzymes
- THC highly lipid soluble
- THC in fat releases slowly
- primary metabolite produces psychoactive effects
elimination of THC
long elimination rate
endocannabinoids
endogenous retrograde neurotransmitters that activate cannabinoid receptors
- anandamide
- 2-AG
cannabinoid receptors
metabotropic
- CB1: CNS
- CB2: Glial/immune system
THC mech of action
partial agonist of CB1
CBD mech of action
- weak affinity for CB1
- antagonist in the presence of THC
- negative modulator of CB1
effects of cannabis
- pain relief
- motor inhibition
- mood elevation
- increased appetite
- cognitive disruption
- suppress immune function (CB2)
