Cardiomyopathies Flashcards Preview

Cardiopulmonary I > Cardiomyopathies > Flashcards

Flashcards in Cardiomyopathies Deck (24)
Loading flashcards...


Big heart


Cardiac dilation

There is hypertrophy of all 4 chambers of the heart which causes the heart to become bigger than normal - it is called the globoid enlargement

Heart will have a lot of fibrous tissue so the heart is going to be very soft and pliable


What is the white stuff that is shown when the heart is cut in vertical section

Subendoacardial fibrosis

This is dilated cardiopathy


2 D's, classic of dilated cardioopathy


What are the pathological changes that take place in dilated cardiopathy

There is hypertrophy and at the same time atrophy in some regions of the cardiac myocytes.

Also you would notice that there is fibrosis of the heart.

There is increased mitochondria and loss of sarcomeres


There is more stroma than muscles



Secondary dilated cardiopathies, why do they happen

1. Toxic cardiomyopathy, like in chemotherapy

2. Cardiomyopathy of pregnancy, happens in the last trimester, it has autorecovery half of the time

3. Viral cardiomyopathy, myocarditis


What are the clinical features of dilated cardiomyopathy

1. Asymptomatic

2. Progressive exercise intolerance

3. CHF

There is no other intervention other than a cardiac transplant


Hypertrphic cardiomyopathy

1. Usually involves left ventricle but it can also involve both of the ventricles, the median septum may also thicken

2. There is assymetry hypertrophy, also called obstructuve cardiomyopathy

3. There are genetic factos associated with this disease


Septum is thicker, this is hypertrophic cardiomyopathy


Myofiber disarray, this happens in hypertrophic cardiomyopathy


Contrast hypertrophic and dilated cardiomyopathy, from what we have learned so far

In dilated there is global enlargement of the heart, whereas in hypertrophic usually the ventricles are involved


What are the clinical features of hypertrophic cardiomyopathies

1. Asymptomatic

2. Associated with sudden death while playing sports or exercising

3. CHF like symptoms


Restrictive cardiomyopathy

These are a group of diseases where the diastolic filling of the heart is impaired such that the heart doesnt fill with sufficient quantities of blood. The contractile function of the heart remains normal

There are 2 ends of the spectrum

Endomyocardial Fibrosis- less aggressive one, happens in young children, leads to CHF and death

Loeffler Endocarditis - happens in men in their 5th decade of their life, more aggressive, CHF and death. Assocaited with hypereosinophilia and myeloperoxidase disorder

Endocardial fibroelastosis - happens in the first 2 years of life, here the pump function of the heart is affected as the LV is the one which is most affected


Pathology of restricitve cardiomyopathies

Fibrosis happens which can dislodge from the heat and occlude a blood vessel. In the pathology we see

1. Grayish white thickened endocardium

2. Mural thrombu

3. Fibrotic endocardium


Restrictive cardiomyopathy


What are the group of diseases that can predispose someone to restrictive cardiomyopathies

1. Amyloidosis

2. Saracoidosis

3. Storage diseases

4. Idiopathic



1. Related to mutiple myeloma

2. Pathology involves cardiomegaly and amyloid infilterate

3. Clinically can be seen as right sided heart failure and arrythmias



Cardiac amyloidosis


What disease is common between dilated and restrictive cardiomyopathies

Sarcoidosis, it is associated with granulomas


Storage disease

Glycogen storage diseases etc etc



Arrythmogenic cardiomyopathies

This diseases is characterized by gradual deposition of adipose and fibroadipose which replace the cardiomyocytes in the ventricles

Also called right ventrucle rythmagenic dysplasia

Bu histology we will see a ton of fact


Arrythmagenic cardiomyopathy