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Flashcards in Lipoprotein structure Deck (10):
1

What are the functions of lipoprotein

It transports cholesterol and lipids from the blood or from the tissues of absorption to the tissues of storage.

2

Abnormalities that result when the lipoproteins do not function right

1. Diabetes 2. Obesity 3. Atherosclerosis

3

What is the structure of lipoproteins

They have a charged outer core and a neutral inner core to carry lipids and cholestrol in blood. The big orange region on the surface is the apolipoprotein that is responsible for transmembrane transport or activating an enzyme

4

What are the different kinds of lipoproteins

There are

1. HDL: smallest, carry the least amount of lipids thats why they are high density

2. LDL: medium in size, carry more lipids than HDL

3. VLDL: intermediate between LDL and chylomicrons

4. Chylomicrons: very large, largest as a matter of fact, carry a lot of lipids, lowest density

5

What is different about HDL and all other lipoproteins

HDL is the smallest and it doesnt have appo-B lipoprotein

6

What is unique about chylomicrons

Largest of the lipoproteins, they contain B containing alipoprotein called the B-48. All the rest of the lipoproteins have B-100 (except for HDL which doesnt have any)

7

What is the significance of B-100 apolioprotein

It is the ligand for LDL receptors

8

Name the major processing proteins associated with lipoproteins and state their functions

1. Lipoprotein lipase (LPL): found in the blood vessels

2. Lecithin:cholestrol acyltransferase (LCAT): it esterifies cholestrol

3. Heaptic triglyceride lipase (HTGL): found in the liver

4. Cholestrol ester transfer protein (CETP): loads cholestrol on the lipoproteins, for example from HDL to VLDL

9

Name the associated receptors and receptor proteins of lipoproteins

1. LDL receptor: found in liver

2. LDL related receptor proteins: found in many tissues

3. Scavenger receptor (SR-A is found on macrophages and SR-B is found on hapatocytes that mediates the uptake of LDL)

4. Cholestrol/phospholipids transport proteins

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