Case 6 Flashcards

to make Jodie happy (45 cards)

1
Q

What is the mechanism of the movement of fluid in and out of the vessels? (oedema)

A

Bulk outward movement is driven by CHP (capillary hydrostatic pressure). Reabsorption is driven by BCOP

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2
Q

What does BCOP stand for

A

Blood colloidal osmotic pressure

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3
Q

Does the Blood colloidal osmotic pressure stay the same in the capillary

A

yes

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4
Q

What is capillary filtration of fluid driven by

A

CHP > BCOP

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5
Q

Why is there no net movement in the middle of capillary

A

CHP=BCOP

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6
Q

What is reabsorption of fluid driven by

A

CHP

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7
Q

What are the layers of the blood vessels

A

Tunica intima, tunica media, tunica externa

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8
Q

What is the primary positive ion found within the cells

A

potassium

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9
Q

What are the normal levels for potassium

A

3.4-5.5mEg/L

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10
Q

What organ regulates potassium

A

Kidneys

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11
Q

What hormone stimulates the elimination of K+ by the kidneys

A

Aldosterone

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12
Q

What is hypernatremia and hyperkalemia

A

Too much sodium and too much potassium

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13
Q

What does aldosterone do to the kidneys in terms of sodium and potassium

A

Causes it to excrete potassium and retain sodium

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14
Q

What is the effect on blood volume on retaining sodium

A

Blood volume increases due to less urine being produced

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15
Q

What is ADH also known as

A

Vassopressin

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16
Q

What is phosphocreatine

A

very high energy compound that gives rise to the waste creatine - a back up for ATP

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17
Q

What could arise in blood creatine concentration be a marker for

A

Damage to functioning nephrons

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18
Q

What is the range of blood pressures in men and women

A

90/60mmHg - 120/80mmHg

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19
Q

How many weeks off sick is long term sick

20
Q

After how many days off sick must an employee give a doctors note

21
Q

What is endocrine hypertension

A

type of high blood pressure caused by a hormone impalance

22
Q

What is Primary hyperaldosteronism

A

when the adrenal glands produce too much aldosterone hormone which raises Na lavels in the blood

23
Q

What is the different between intrinsic and extrinsic controls of the heart

A

Intrinsic regulation of heart rate is the result of the unique nature of cardiac tissue self-regulating itself
Extrinic is hormones and nervous system

24
Q

How does the sympathetic components increase heart rate

A

releasing - catecholamines - (epinephrine and norepinephrine)

25
How does the parasympathetic nervous system slow heart rate
acethlcholine inhibits heart rate thus slowing it down
26
What do chronotropic drugs do
change heart rate AND rhythm
27
What nerves carry 80% of parasympathetic fibers
vagus
28
It an abnormal noise is heart outside the heat what is it called
Outside is a bruit
29
What is an abnornal noise inside the heart called
murmur
30
What primarily metabolises nicotine
CYP2A6
31
What does the variability in (CYP2A6) the rate of metabolism contribute to
vulnerability to tobacco dependence
32
What does nicotine bind to
nAChRs
33
What is nicotine a similar shape to
Ach
34
What happens in terms of repeated use of nicotine
After repeated use of nicotine, there is more activity at the acetylcholine receptors than usual because the receptors are being activated by both acetylcholine and nicotine. This change in balance causes the brain to “think” there is too much acetylcholine and react by reducing the number of receptors and releasing less acetylcholine into the synapse. The brain now needs nicotine to maintain normal functioning. Nicotine reduces the actions of the parasympathetic nervous system. It decreases the amount of AcH binding to nicotinic receptors thus less parasympathetic nervous system. These changes in the brain cause a nicotine user to feel abnormal when not using nicotine. In order to feel normal, the user has to keep his or her body supplied with nicotine. This is addiction. If the person stops using nicotine, the number of receptors and their sensitivity to acetylcholine will eventually be re-established, but only after some time.
35
What are the mechanism in which cigarette smoking is likely to contribute to accute vascular events
1) induction of a hypercoagulable state (artery’s clogging and clot forming) 2) increased myocardial work; 3) carbon monoxide–mediated reduced oxygen-carrying capacity of the blood; 4) coronary vasoconstriction; and 5) catecholamine release.
36
What two homrones released by stress can cause hypertension and why
* Epinephrine: Most people know epinephrine by its other name—adrenaline. This hormone rapidly responds to stress by increasing your heart rate and rushing blood to the muscles and brain. It also spikes your blood sugar level by helping convert glycogen to glucose in the liver. (Glycogen is the liver’s storage form of glucose.) * Norepinephrine: Also known as noradrenaline, this hormone works with epinephrine in responding to stress. However, it can cause vasoconstriction (the narrowing of blood vessels). This results in high blood pressure.
37
Why does high blood pressure lead to oedema
High blood pressure makes heart muscle thicker and less effective. This allows fluid to build u in lower legs and ankles which causes them to swell up.
38
What is another way high blood pressure can lead to oedema (kidneys)
High blood pressure causes the adrenal cortex of the kidney to reduce Na thus water follows. However high BP thearteries supplying th kidneys are thicker thus kidneys think that BP has fallen causing the adrenal cortex to secrete aldosterone thus it absorbs Na thus water follows further raising BP
39
What can happen to the aorta if high blood pressure is untreated
AAA
40
What can high blood pressure lead to
TIA (transient ischemic attack) ect
41
What are the normal ranges for cholesterol
Total cholesterol 5mmol/L for healthy adult 4mmol/L for adult at high risk LDL 3mmol/L or less for healthy adults 2mmol/L or less for those at high risk Ratio is Total / HDL SHould be below 4
42
What do electrolytes do
move nutrients and waste around and out of the bodys cells maintains pH
43
Where is the majority of the bodies sodium found
Extracellular fluid outside cells
44
what are all parasympathetic nerves
cranial or sacral
45
what are all sympathetic nerves
cervical, thoracic or lumbar