Drugs of case 6

Question 1

What kind of blood vessels foes amlodipine favour

Answer 1

peripheral blood vessels

Question 2

What is the mechanism of amlodipine

Answer 2

It is an antagonist for L-type calcium channels and inhibits Ca2+ ions
Thus decreases cardiac output by reducing pressure as smooth muscle contractility and vasoconstriction of blood vessels

Question 3

What is very bad for calcium channel blockers

Answer 3

grapefruit juice as increases serum amlodipine levels to a toxic level

Question 4

What type of drug is chlorthalidone

Answer 4

Thiazide diuretic

Question 5

What is the mechanism of Chlorthalidone

Answer 5

Targets the Na/cl cotransporter by binding to Cl binding site thus reducing water reabsorption as co transporter can’t work

Question 6

What type of drug is candesartan

Answer 6

Angiotensin 2 receptor antagonist

Question 7

Is candesartan a pro drug

Answer 7

Yes Jodie

Question 8

What is the mechanism of candesartan

Answer 8

Blocks angiotensin 2 and inhibits vasoconstriction thus lowers blood pressure

Question 9

What type of drug is Indapamide

Answer 9

Thiazide LIKE diuretic

Question 10

What is the mechanism of indapamide

Answer 10

Not very well known
Inhibits Cl
Reduces blood pressure by reducing the amount of water uptaken
Indapamide blocks the slow component of K currents